Effect of Oral Enrofloxacin and Florfenicol on Pigs Experimentally Infected with Actinobacillus pleuropneumoniae Serotype 1

• Published in: Journal of veterinary medicine. Series A Vol. 50; no. 5; pp. 259 - 263
• Main Authors: Herradora, L. M. A., Martínez-Gamba, R.
• Format: Journal Article
• Language: English
• Published: Berlin, Germany Blackwell Verlag GmbH 01.06.2003
• Subjects: Actinobacillus Infections - drug therapy; Actinobacillus Infections - veterinary; Actinobacillus pleuropneumoniae - classification; Actinobacillus pleuropneumoniae - pathogenicity; Administration, Oral; Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - therapeutic use; Body Temperature; Fluoroquinolones; Male; Quinolones - administration & dosage; Quinolones - therapeutic use; Swine; Swine Diseases - drug therapy; Swine Diseases - pathology; Thiamphenicol - administration & dosage; Thiamphenicol - analogs & derivatives; Thiamphenicol - therapeutic use; Treatment Outcome
• ISSN: 0931-184X; 1439-0442
• DOI: 10.1046/j.1439-0442.2003.00529.x

Summary This study was carried out to compare the efficacy of two oral anti‐microbials as metaphylactic medication to pigs inoculated with Actinobacillus pleuropneumoniae serotype 1. Forty‐two pigs with an average weight of 22.64 kg were randomly assigned to three treatment groups: group F was given doses of 40 ppm of florfenicol, group E received 150 ppm of enrofloxacin and group C received no medication. Groups F and E received medicated feed 12 h before being inoculated and for 7 days after inoculation. All the pigs were inoculated by aerosol, with 2 × 107 CFU/ml of A. pleuropneumoniae serotype 1 each. The average body temperature was higher in group C than in groups E and F, between 12 and 96 h after inoculation (P < 0.05). No differences were found between groups F and E in respiration pattern, nasal secretion and general condition (P > 0.05); however, differences were found in group C for respiration pattern and general condition (P < 0.05), 12 h after inoculation. There was no mortality in groups F and E, whereas a 50% mortality was recorded in group C during the first 48 h after inoculation (P < 0.05). Necropsies and bacterial cultures were performed 12 days after inoculation. Lesions were observed in five pigs of group F (35.71%) with an average damage of 1.16%; in four pigs of group E (28.57%) with 1.24%; and in 13 animals in group C (92.85%) with 34.5% of affected lung tissue (P < 0.05). The infective agent was cultured from various organs of animals in groups F and C, but not from those in group E.