Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia

Glutamate decarboxylase (GAD) activity was measured in the nuclei of the basal ganglia in patients with neuroleptic-induced tardive dyskinesia (TD) and controls matched for age and premortem state. In five TD patients, who all had a sudden death, a significant decrease in GAD activity was found in t...

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Bibliographic Details
Published inMovement disorders Vol. 4; no. 1; p. 37
Main Authors Andersson, U, Häggström, J E, Levin, E D, Bondesson, U, Valverius, M, Gunne, L M
Format Journal Article
LanguageEnglish
Published United States 1989
Subjects
Aged
Aged, 80 and over
Death, Sudden - pathology
Dyskinesia, Drug-Induced - pathology
Female
Glutamate Decarboxylase - deficiency
Humans
Male
Middle Aged
Myocardial Infarction - pathology
Thalamic Nuclei - pathology
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Summary:Glutamate decarboxylase (GAD) activity was measured in the nuclei of the basal ganglia in patients with neuroleptic-induced tardive dyskinesia (TD) and controls matched for age and premortem state. In five TD patients, who all had a sudden death, a significant decrease in GAD activity was found in the subthalamic nucleus (STN). The lowered GAD activity in the STN may represent a biochemical substrate for neuroleptic-induced TD.
ISSN:0885-3185
DOI:10.1002/mds.870040107