A case of adult-onset dementia with argyrophilic grains

A case of progressive dementia in a 68-year-old woman was characterized by the postmortem finding of widespread argyrophilic grains in the cerebral cortex. The grains consisted of 10- to 13-nm filaments in deposits ranging up to 9 microns in length and 3 microns in diameter. The grains stained posit...

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Bibliographic Details
Published inAnnals of neurology Vol. 26; no. 5; p. 685
Main Authors Itagaki, S, McGeer, P L, Akiyama, H, Beattie, B L, Walker, D G, Moore, G R, McGeer, E G
Format Journal Article
LanguageEnglish
Published United States 01.11.1989
Subjects
Aged
Antibodies, Monoclonal
Antigens - metabolism
Brain - metabolism
Brain - pathology
Cytoplasmic Granules - metabolism
Cytoplasmic Granules - pathology
Dementia - metabolism
Dementia - pathology
Female
Humans
Immunohistochemistry
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Summary:A case of progressive dementia in a 68-year-old woman was characterized by the postmortem finding of widespread argyrophilic grains in the cerebral cortex. The grains consisted of 10- to 13-nm filaments in deposits ranging up to 9 microns in length and 3 microns in diameter. The grains stained positive with Alz-50 monoclonal antibody. Cortical brain tissue levels were minimally elevated for acetylcholinesterase, moderately reduced for choline acetyltransferase, and sharply reduced for glutaminase. Although the case was clinically indistinguishable from Alzheimer's disease, plaque and tangle pathological findings were absent. We confirm cortical changes of the type described by Braak and Braak and provide additional data on subcortical changes in this case.
ISSN:0364-5134
DOI:10.1002/ana.410260517