Single‐cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8+ αβ T lymphocytes in untreated celiac disease

We compared the αβ T‐cell receptor repertoires of CD8+ αβ intraepithelial lymphocytes from celiac disease patients and healthy subjects by single‐cell sequencing. We demonstrate that the repertoires of untreated celiac disease patients were more polyclonal and more diverse than what was observed in...

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Published inEuropean journal of immunology Vol. 51; no. 6; pp. 1542 - 1545
Main Authors Eggesbø, Linn M., Risnes, Louise F., Neumann, Ralf S., Lundin, Knut E. A., Christophersen, Asbjørn, Sollid, Ludvig M.
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.06.2021
Subjects
CD8 antigen
CD8+ αβ T cells
Celiac disease
intraepithelial lymphocytes
Lymphocytes T
single cell sequencing
T cell receptors
TCR
celiac disease
single cell sequencing
TCR
CD8+ αβ T cells
intraepithelial lymphocytes
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Summary:We compared the αβ T‐cell receptor repertoires of CD8+ αβ intraepithelial lymphocytes from celiac disease patients and healthy subjects by single‐cell sequencing. We demonstrate that the repertoires of untreated celiac disease patients were more polyclonal and more diverse than what was observed in both treated patients and healthy subjects.
Bibliography:The authors contributed equally to this work
SourceType-Scholarly Journals-1
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ObjectType-Editorial-2
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ISSN:0014-2980
1521-4141
1521-4141
DOI:10.1002/eji.202048974