Effect of a seaweed mixture on serum lipid level and platelet aggregation in rats

• Published in: Fisheries science Vol. 71; no. 5; pp. 1160 - 1166
• Main Authors: Amano, H.(Mie Univ., Tsu (Japan). Faculty of Bioresources), Kakinuma, M, Coury, D.A, Ohno, H, Hara, T
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Pty 01.10.2005; Springer Nature B.V
• Subjects: Algae; ALGAS MARINAS; ALGUE MARINE; blood; BLOOD SERUM; CHOLESTEROL; COLESTEROL; CONTENIDO DE LIPIDOS; Eisenia bicyclis; HIPERLIPIDEMIA; Hizikia fusiforme; HYPERLIPIDAEMIA; HYPERLIPIDEMIE; lipid; LIPID CONTENT; platelet anti‐aggregation; PLATELETS; Porphyra yezoensis; Prevention; RAT; RATA; RATS; Rodents; seaweed mixture; SEAWEEDS; serum; SERUM SANGUIN; SUERO SANGUINEO; TENEUR EN LIPIDES; THROMBOCYTE; Thromboembolism; THROMBOSE; THROMBOSIS; TROMBOCITOS; TROMBOSIS; Undaria pinnatifida
• ISSN: 0919-9268; 1444-2906
• DOI: 10.1111/j.1444-2906.2005.01076.x

To assess the effect of a seaweed mixture on lipid levels in serum as well as platelet aggregation in rats, Eisenia bicyclis (‘Arame’), Hizikia fusiformis (‘Hijiki’) and Undaria pinnatifida sporophylls (‘Mekabu’), all brown seaweeds, and Porphyra yezoensis (‘Susabinori’), a red seaweed, were powdered and mixed in a ratio of 45:30:20:5 (w/w). When rats were fed a cholesterol‐rich diet containing this mixture of seaweeds (9–10% w/w) for 28 days, serum total cholesterol, LDL‐cholesterol, free cholesterol, and triglyceride levels declined significantly to 49.7%, 48.1%, 49.0% and 74.8%, respectively, of those of the control. Serum HDL‐cholesterol, however, was unchanged. Though activated partial thromboplatin time, prothrombin time, antithrombin III activity, and fibrinogen levels in plasma were unchanged, the maximal ADP‐ and collagen‐induced platelet aggregation decreased significantly to 89.0% and 85.5% control levels, respectively. These results indicate that this mixture of E. bicyclis, H. fusiformis, U. pinnatifida sporophylls, and P. yezoensis, is useful for the prevention of hyperlipidemia and thrombosis in rats.