SYNTHESIS OF 3,5-DICHLORO-6-ETHYL-2,4-DIHYDROXYBENZOIC ACID - THE AROMATIC CONSTITUENT OF LIPIARMYCIN-A3

3,5-Dichloro-6-ethyl-2,4-dihydroxybenzoic acid (5, homodichloroorsellinic acid) is the polysubstituted aromatic carboxylic acid found in the macrolide antibiotic lipiarmycin A3. A convenient synthesis of the title compound from ethyl 2-pentenoate and ethyl acetoacetate is described (five steps, 41%...

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Bibliographic Details
Published inLiebigs Annalen der Chemie no. 12; pp. 1363 - 1364
Main Authors ALEXY, M, SCHARF, HD
Format Journal Article
LanguageEnglish
Published DEERFIELD BEACH Wiley 1991
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
LIPIARMYCIN
ANTIBIOTICS
BENZOIC ACID, 3,5-DICHLORO-6-ETHYL-2,4-DIHYDROXY
MACROLIDE ANTIBIOTIC
ACTINOPLANES
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Summary:3,5-Dichloro-6-ethyl-2,4-dihydroxybenzoic acid (5, homodichloroorsellinic acid) is the polysubstituted aromatic carboxylic acid found in the macrolide antibiotic lipiarmycin A3. A convenient synthesis of the title compound from ethyl 2-pentenoate and ethyl acetoacetate is described (five steps, 41% overall yield).
ISSN:0170-2041
DOI:10.1002/jlac.1991199101235