A genotoxicological study of the new local anaesthetic carbamate derivatives carbisocaine, heptacaine and pentacaine

The potential mutagenic activity of three carbamate derivatives with local anaesthetic activity was investigated. Genotoxic activity was observed after application of Carbisocaine on Euglena gracilis, whereas no activity was detected by Carbisocaine, Heptacaine and Pentacaine on Salmonella typhimuri...

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Bibliographic Details
Published inJournal of applied toxicology Vol. 10; no. 4; p. 239
Main Author Siekel, P
Format Journal Article
LanguageEnglish
Published England 01.08.1990
Subjects
Anesthetics, Local - toxicity
Animals
Carbamates - toxicity
DNA Repair - drug effects
Drosophila melanogaster - genetics
Escherichia coli - drug effects
Escherichia coli - genetics
Euglena - drug effects
Euglena - genetics
Genes, Lethal - drug effects
Genes, Recessive - drug effects
Mutagenicity Tests
Mutagens
Piperidines - toxicity
Salmonella typhimurium - genetics
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Summary:The potential mutagenic activity of three carbamate derivatives with local anaesthetic activity was investigated. Genotoxic activity was observed after application of Carbisocaine on Euglena gracilis, whereas no activity was detected by Carbisocaine, Heptacaine and Pentacaine on Salmonella typhimurium, Escherichia coli and Drosophila melanogaster.
ISSN:0260-437X
DOI:10.1002/jat.2550100403