Susceptibility of human and murine Chlamydia trachomatis serovars to granulocyte- and epithelium-derived antimicrobial peptides

: Four antimicrobial peptides, protegrin‐1, RTD‐1, cryptdin‐4, and indolicidin, were tested for their ability to inhibit the in vitro growth of Chlamydia trachomatis serovars E, L2, and mouse pneumonitis (MoPn). In general, protegrin‐1 was found to have the strongest anti‐chlamydial activity. Overal...

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Bibliographic Details
Published inThe journal of peptide research Vol. 61; no. 5; pp. 237 - 242
Main Authors Chong-Cerrillo, C., Selsted, M.E., Peterson, E.M., De La Maza, L.M.
Format Journal Article
LanguageEnglish
Published Oxford, UK Munksgaard International Publishers 01.05.2003
Subjects
alpha-Defensins
Animals
Anti-Infective Agents - pharmacology
Antimicrobial Cationic Peptides - pharmacology
antimicrobial peptides
Chlamydia trachomatis
Chlamydia trachomatis - drug effects
Chlamydia trachomatis - growth & development
cryptdin-4
Defensins - pharmacology
Dose-Response Relationship, Drug
Epithelial Cells
Granulocytes
Humans
indolicidin
Mice
Peptides - pharmacology
Peptides, Cyclic - pharmacology
protegrin-1
Proteins - chemical synthesis
Proteins - pharmacology
Rabbits
RTD-1
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Summary:: Four antimicrobial peptides, protegrin‐1, RTD‐1, cryptdin‐4, and indolicidin, were tested for their ability to inhibit the in vitro growth of Chlamydia trachomatis serovars E, L2, and mouse pneumonitis (MoPn). In general, protegrin‐1 was found to have the strongest anti‐chlamydial activity. Overall, of the three serovars tested, L2 was the most susceptible while MoPn was the most resistant to these peptides.
Bibliography:istex:3C9C4905843CAF1661A3F3628C03C1D9A0C3D81D
ArticleID:CBDD053
ark:/67375/WNG-NRHNDKFN-0
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1397-002X
1399-3011
DOI:10.1034/j.1399-3011.2003.00053.x