Optimization of the properties of chitosan lactate/hyaluronan film

• Published in: Journal of applied polymer science Vol. 100; no. 2; pp. 1413 - 1419
• Main Authors: Kukolikova, L., Bakos, D., Alexy, P., Hanzelova, S., Zhong, W.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.04.2006; Wiley
• Subjects: Applied sciences; Biological and medical sciences; biopolymers; crosslinking; Exact sciences and technology; Medical sciences; Natural polymers; Physicochemistry of polymers; polyelectrolytes; Starch and polysaccharides; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Biological properties; films; Swelling; Biodegradability; Mechanical properties; Crosslinking; Experimental study; Property processing relationship; polyelectrolytes; Optimization; Polyelectrolyte; Chitosan derivatives; Starch dialdehyde; Experimental design; Preparation; Crosslinked polymer; Enzymatic digestion; Glycosaminoglycan; Oside polymer; Biomaterial; Interpolymer; biopolymers; Hyaluronic acid
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.23273

Polyelectrolyte complexes represent attractive class of polymer‐based materials, finding an irreplaceable role in biomaterial preparation for tissue engineering or drug delivery beads. Mechanical properties, physical properties, and enzymatic degradation of the film prepared from chitosan lactate/hyaluronan polyelectrolyte complex, crosslinked with starch dialdehyde derivatives, were studied to optimize its composition. This work represents an example demonstrating how a minor modification of the modified complex composition changes final properties of the prepared film and emphasizes enormous variations in complex formation by crosslinking. To obtain sufficiently useful information, experimental design was employed. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 1413–1419, 2006