Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection

Prosthetic joint infection is usually caused by staphylococci. Among the coagulase-negative staphylococci, Staphylococcus lugdunensis is important because it behaves as a pathogen similar to S aureus. It also develops biofilms, and the biofilm phenotype can appear as small-colony variants. Although...

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Bibliographic Details
Published inArthroplasty today Vol. 4; no. 3; pp. 257 - 260
Main Authors Askar, Mohamed, Bloch, Benjamin, Bayston, Roger
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2018
Elsevier
Subjects
Case Report
Infection
Joint
lugdunensis
Prosthetic
Staphylococcus
Infection
Prosthetic
Joint
Staphylococcus
lugdunensis
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Summary:Prosthetic joint infection is usually caused by staphylococci. Among the coagulase-negative staphylococci, Staphylococcus lugdunensis is important because it behaves as a pathogen similar to S aureus. It also develops biofilms, and the biofilm phenotype can appear as small-colony variants. Although genetically indistinguishable, they differ in size and antibiotic susceptibility from the parent strain and are responsible for chronic persistent infection and failure of antibiotic treatment. They can also lead to misinterpretation of results. The patient reported here underwent total knee replacement and 2 years later presented with prosthetic joint infection. Tissue samples and prosthesis taken at revision grew S lugdunensis, the majority of which were small-colony variants. Recommendations are made for their detection and identification.
ISSN:2352-3441
2352-3441
DOI:10.1016/j.artd.2018.06.003