Comparison of Impedance Minute Ventilation and Direct Measured Minute Ventilation in a Rate Adaptive Pacemaker

• Published in: Pacing and clinical electrophysiology Vol. 26; no. 11; pp. 2127 - 2133
• Main Authors: SIMON, RON, NI, QUAN, WILLEMS, ROGER, HARTLEY, JESSE W., DAUM, DOUGLAS R., LANG, DOUGLAS, WARD, KEVIN, GILL, JASWINDER
• Format: Journal Article
• Language: English
• Published: 350 Main Street , Malden , MA 02148-5018 , U.S.A Blackwell Publishing 01.11.2003
• Subjects: Adult; Aged; Algorithms; Calibration; Cardiography, Impedance; Exercise Test; Female; Humans; impedance; Male; Middle Aged; minute ventilation; pacemaker; Pacemaker, Artificial; Posture; Pulmonary Ventilation
• ISSN: 0147-8389; 1540-8159
• DOI: 10.1046/j.1460-9592.2003.00331.x

Respiration rate (RR) and minute ventilation (MV) provide important clinical information on the state of the patient. This study evaluated the accuracy of determining these using a pacemaker impedance sensor. In 20 patients who were previously implanted with a Guidant PULSAR MAX group of pacemakers, the telemetered impedance sensor waveform was recorded simultaneously with direct volume respiration waveforms as measured by a pneumatometer. Patients underwent 30 minutes of breathing tests while supine and standing, and a 10‐minute ergonometer bicycle exercise test at a workload of 50 W. Breathing tests included regular and rapid‐shallow breathing sequences. RR was determined by a computerized algorithm, from impedance and respiration signals. The mean RR by impedance was 21.3 ± 7.7 breaths/min, by direct volume was 21.1 ± 7.6 breaths/min, range 7–66, the mean difference of RR measured by the impedance sensor, as compared with the true measurement, being 0.2 ± 2.1 breaths/min. During the entire exercise, the mean correlation coefficient between impedance (iMV) and direct measured MV was 0.96 ± 0.03, slope 0.13 ± 0.05 L/Ω and range 0.07–0.26 L/Ω. Bland‐Altman limits of agreement were ± 4.6 L/min for MV versus iMV with each patient calibrated separately. The correlation coefficient for iMV versus MV over the entire 10 minutes of exercise, including the initial 4 minutes of exercise, was 0.99. The transthoracic impedance sensor of an implanted pacemaker can accurately detect respiration parameters. There was a large variation between subjects in the iMV versus MV slope during a bicycle exercise test, whereas for each subject, the slope was stable during submaximal bicycle exercise. (PACE 2003; 26:2127–2133)