Influx of nonactivated T lymphocytes into the cerebrospinal fluid during relapse of multiple sclerosis

T lymphocytes were analyzed in the cerebrospinal fluid of 17 patients with multiple sclerosis during and 2 months after an exacerbation. The percentage of activated (HLA-DR+) T lymphocytes was decreased in the cerebrospinal fluid during the relapse but returned thereafter to the level comparable to...

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Bibliographic Details
Published inAnnals of neurology Vol. 38; no. 3; p. 465
Main Authors Oksaranta, O, Tarvonen, S, Ilonen, J, Poikonen, K, Reunanen, M, Panelius, M, Salonen, R
Format Journal Article
LanguageEnglish
Published United States 01.09.1995
Subjects
Adult
CD3 Complex - immunology
Female
Humans
Male
Middle Aged
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - immunology
Multiple Sclerosis - physiopathology
Recurrence
T-Lymphocytes - immunology
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Summary:T lymphocytes were analyzed in the cerebrospinal fluid of 17 patients with multiple sclerosis during and 2 months after an exacerbation. The percentage of activated (HLA-DR+) T lymphocytes was decreased in the cerebrospinal fluid during the relapse but returned thereafter to the level comparable to that in patients with noninflammatory neurological diseases, whereas no fluctuation in the total number of these cells was found. This suggests an influx of nonactivated T lymphocytes into the cerebrospinal fluid at the beginning of the relapse.
ISSN:0364-5134
DOI:10.1002/ana.410380320