PROGNOSTIC ROLE OF CD44 EXPRESSION AND NEOVASCULARIZATION DETERMINED BY ENDOGLIN (CD105) IN GLIOBLASTOMA PATIENTS

Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Clinically useful molecular markers that help predict response to therapy and prognosis are still rare. The research was conducted in 55 patients with GBM, 26 (47.3%) women and 29 (52.7%) me...

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Published inActa clinica Croatica (Tisak) Vol. 58; no. 3; pp. 455 - 462
Main Authors Mihić, Josip, Rotim, Krešimir, Vučić, Majda, Hude Dragičević, Ida, Borić, Marta, Lugović-Mihić, Liborija
Format Journal Article
LanguageEnglish
Published Croatia Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb 01.09.2019
Subjects
Antibodies - analysis
Biomarkers, Tumor - analysis
Brain Neoplasms - diagnosis
Brain Neoplasms - immunology
Brain Neoplasms - pathology
Endoglin - immunology
Female
Glioblastoma - diagnosis
Glioblastoma - immunology
Glioblastoma - pathology
Humans
Hyaluronan Receptors - immunology
Immunohistochemistry
Male
Middle Aged
Neovascularization, Pathologic - diagnosis
Neovascularization, Pathologic - immunology
Original Scientific Papers
Predictive Value of Tests
Prognosis
Immunohistochemistry
Endoglin
Brain neoplasms
Prognosis
CD44 protein, human
Glioblastoma
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Summary:Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Clinically useful molecular markers that help predict response to therapy and prognosis are still rare. The research was conducted in 55 patients with GBM, 26 (47.3%) women and 29 (52.7%) men, mean age 62.58 years. On immunohistochemical analysis, primary antibody to CD44 (dilution 1:50) and primary antibody to endoglin (CD105) (dilution 1:250) were used to evaluate neovascularization. Statistical analysis showed negative correlation between CD44 and survival (p=0.023) (higher expression of CD44 was correlated with shorter survival), but there was no correlation between neovascularization determined by CD105 in GBM and patient survival. Thus, significant individual predictors of longer survival were lower expression of CD44 (p=0.004), higher Karnofsky score (p=0.045), and female gender (p=0.017). The results obtained suggested the possible role of CD44 in the progression and tumor neovascularization of GBM.
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ISSN:0353-9466
1333-9451
DOI:10.20471/acc.2019.58.03.08