Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications
The present study is focused on the synthesis and characterization of nitric oxide (NO)-releasing superparamagnetic iron oxide nanoparticles (Fe 3 O 4 NPs), and their incorporation in Pluronic F127 hydrogel with great potential for topical applications. Magnetite nanoparticles (Fe 3 O 4 NPs) were sy...
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Published in | RSC advances Vol. 7; no. 24; pp. 14496 - 14503 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Cambridge
Royal Society of Chemistry
2017
|
Subjects | |
Online Access | Get full text |
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Summary: | The present study is focused on the synthesis and characterization of nitric oxide (NO)-releasing superparamagnetic iron oxide nanoparticles (Fe
3
O
4
NPs), and their incorporation in Pluronic F127 hydrogel with great potential for topical applications. Magnetite nanoparticles (Fe
3
O
4
NPs) were synthesized by thermal decomposition of acetylacetonate iron (Fe(acac)
3
), and coated with the thiol containing molecule mercaptosuccinic acid (MSA), leading to Fe
3
O
4
-MSA NPs. The obtained NPs were characterized using different techniques. The results showed that the Fe
3
O
4
-MSA NPs have a mean diameter of 11 nm, in the solid state, and superparamagnetic behavior at room temperature. Fe
3
O
4
-MSA NPs have an average hydrodynamic size of (78.0 ± 0.9) nm, average size distribution (PDI) of 0.302 ± 0.04, and zeta potential of (−22.10 ± 0.55) mV. Free thiol groups on the Fe
3
O
4
-MSA NP surface were nitrosated by the addition of sodium nitrite, yielding
S
-nitrosated magnetic nanoparticles (Fe
3
O
4
-
S
-nitroso-MSA NPs), which act as spontaneous NO donors upon S–N bond cleavage. The amount of (86.4 ± 4.7) μmol of NO was released per gram of Fe
3
O
4
-
S
-nitroso-MSA NPs. In order to enhance NP dispersion, Fe
3
O
4
-MSA NPs were incorporated in Pluronic F127 hydrogel (3.4% w/w), and characterized using different techniques. Rheological measurements suggest a potential use for Fe
3
O
4
-MSA NPs dispersed in Pluronic hydrogel for topical applications. Atomic force microscopy (AFM) showed that the NPs are embedded within the Pluronic film while the X-ray photoelectron spectroscopy (XPS) spectrum of the Fe
3
O
4
-MSA NPs samples revealed the presence of iron, oxygen, carbon and sulfur, confirming the presence of MSA molecules on the NP surface. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/C6RA28633J |