CEMBRANE SYNTHESIS - AN ADVANCED INTERMEDIATE FOR CRASSIN ACETATE
The intramolecular alkylation of a lithioalkyne with a allylic bromide produced the fourteen membered ring of crassin acetate. A nitrile oxide cycloaddition furnished the lactone and stereocenters at C1 and C14.
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Published in | Tetrahedron letters Vol. 32; no. 30; pp. 3605 - 3608 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier
22.07.1991
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Subjects | |
Online Access | Get more information |
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Summary: | The intramolecular alkylation of a lithioalkyne with a allylic bromide produced the fourteen membered ring of crassin acetate. A nitrile oxide cycloaddition furnished the lactone and stereocenters at C1 and C14. |
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ISSN: | 0040-4039 |
DOI: | 10.1016/S0040-4039(00)79786-3 |