Early life factors, gray matter brain volume and academic performance in overweight/obese children: The ActiveBrains project

• Published in: NeuroImage (Orlando, Fla.) Vol. 202; p. 116130
• Main Authors: Solis-Urra, Patricio, Esteban-Cornejo, Irene, Cadenas-Sanchez, Cristina, Rodriguez-Ayllon, Maria, Mora-Gonzalez, Jose, Migueles, Jairo H., Labayen, Idoia, Verdejo-Román, Juan, Kramer, Arthur F., Erickson, Kirk I., Hillman, Charles H., Catena, Andrés, Ortega, Francisco B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.11.2019; Elsevier Limited
• Subjects: Academic achievement; Aerobic capacity; Age; Birth weight; Body mass index; Body weight; Brain; Brain structure; Breast feeding; Breastfeeding & lactation; Cerebellum; Childhood; Children; Cognition; Early programming; Frontal gyrus; Gestational age; Health risk assessment; Mathematics; Nutrition; Obesity; Occipital lobe; Operculum; Overweight; Putamen; Rectum; Substantia grisea; Temporal cortex; Temporal gyrus; Thalamus; Academic achievement; SD; Early programming; MRI; CRF; Childhood; Aerobic capacity; Brain structure; BMI; PHV
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2019.116130

Early life factors may influence brain and academic outcomes later in life, especially during childhood. Here we investigate the associations of early life factors (i.e., birth weight, birth length, and breastfeeding) with gray matter volume, adjusted for body mass index and cardiorespiratory fitness, and ii) we test whether early-life factor-related differences in gray matter volume are associated with academic performance in overweight/obese children. 96 children with overweight/obesity aged 8–11 years participated. Birth weight, birth length and gestational age were collected from birth records, and breastfeeding practices were asked to parents. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Academic performance was assessed with the Bateria III Woodcock-Muñoz Tests of Achievement. Whole-brain voxel-wise multiple regressions were used to test the associations of each early life factor with gray matter volume. Higher birth weight and birth length were associated with greater gray matter volume in 9 brain regions including the middle frontal gyrus, rectal gyrus, thalamus, putamen, middle temporal gyrus, lingual gyrus, middle occipital gyrus, calcarine cortex and cerebellum bilaterally (β ranging from 0.361 to 0.539, t ranging from 3.46 to 5.62 and cluster size from 82 to 4478 voxels; p < 0.001); and greater duration of any breastfeeding was associated with greater gray matter volume in 3 regions including the bilateral inferior frontal gyrus and rolandic operculum (β ranging from 0.359 to 0.408, t ranging from 4.01 to 4.32 and cluster size from 64 to 171 voxels; p < 0.001). No associations were found for duration of exclusive breastfeeding. Additionally, none of the gray matter regions that were associated with the early life factors were associated with academic performance (all p > 0.05). Our results demonstrate that birth weight, birth length, and breastfeeding are predictive of gray matter volume of numerous brain structures that are involved in higher order cognition and emotion regulation, but how these results relate to measures of academic achievement remain a matter of speculation. •Early life factors were associated with several regions of gray matter volume in overweight/obese children.•Prenatal and perinatal environment may play a role in gray matter development independently of BMI and CRF.•How these results relate to academic achievement remains a matter of speculation.