T cell factor 1: A master regulator of the T cell response in disease

Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly duri...

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Bibliographic Details
Published inScience immunology Vol. 5; no. 53
Main Authors Escobar, Giulia, Mangani, Davide, Anderson, Ana C
Format Journal Article
LanguageEnglish
Published United States 06.11.2020
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Summary:Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly during disease-induced inflammatory states such as autoimmunity, cancer, and chronic infections. Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies.
ISSN:2470-9468
DOI:10.1126/sciimmunol.abb9726