Apparent finger systolic pressures during cooling in patients with Raynaud's syndrome

• Published in: Circulation (New York, N.Y.) Vol. 77; no. 5; pp. 988 - 996
• Main Authors: CARTER, S. A, DEAN, E, KROEGER, E. A
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.05.1988
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Chronic Disease; Cold Temperature; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Fingers - blood supply; Fingers - physiopathology; Humans; Medical sciences; Middle Aged; Myocardial Contraction; Raynaud Disease - diagnosis; Raynaud Disease - physiopathology; Skin Temperature; Systole; Vasoconstriction; Vasomotor System - physiopathology; Human; Raynaud syndrome; Systolic pressure; Skin disease; Cold; Test; Finger; Diseases of the autonomic nervous system; Vascular disorders of the skin; Cardiovascular disease; Hemodynamics
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/01.CIR.77.5.988

Despite considerable research, the mechanisms responsible for the vasospasm associated with Raynaud's syndrome are not well understood and there is no reliable diagnostic test. In the present studies, measurements of systolic pressure in locally cooled fingers were used to address these issues. We found that local cooling produced a marked decrease or loss of the apparent finger systolic pressure in patients with Raynaud's syndrome in whom a standardized vasoconstriction had been induced by body cooling. Abnormal responses were encountered in 109 of 125 patients with secondary Raynaud's syndrome, in 21 of 37 patients with primary Raynaud's disease or the syndrome of uncertain cause, and in two of 63 subjects without symptoms of Raynaud's. These data suggest a high accuracy of the test in patients with secondary Raynaud's syndrome and lower accuracy in those with disease of primary or uncertain cause. We studied responses of systolic pressures to alterations in body and local temperatures in fingers with and without low pressures secondary to proximal arterial obstruction. Our data show that although local cooling has a small independent effect that increases vascular tone: (1) sympathetic vasoconstriction induced by body cooling is necessary to produce vasospasm and often produces it without local cooling, (2) high local temperature (30 degrees C) protects from vasospasm, and (3) low finger blood pressure predisposes to it. Delayed opening of the vessels observed after sudden deflation of blood pressure cuffs suggests that abnormal responses of finger systolic pressure to cold represent combined effects of high vascular tone, delayed opening, and local blood pressure.