Synthesis and biological activity of artificial analogs of mycalamide A

Artificial analogs of mycalamide A, a potent antitumor and antiviral compound isolated from a New Zealand marine sponge, were synthesized and their biological activities were tested. Artificial analogs of mycalamide A, a potent antitumor and antiviral compound isolated from a New Zealand marine spon...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 7; no. 16; pp. 2081 - 2086
Main Authors Fukui, Hideto, Tsuchiya, Yoshinori, Fujita, Keiko, Nakagawa, Tadakiyo, Koshino, Hiroyuki, Nakata, Tadashi
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 19.08.1997
Elsevier
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Antineoplastic agent
Varicella zoster virus
Herpesviridae
Hydroxyamide
Alphaherpesvirinae
Saturated compound
Pyran derivatives
Oxygen heterocycle
In vitro
Hela cell line
Virus
Herpesvirus hominis 1
Structure activity relation
Established cell line
Bicyclic compound
Antiviral
Chemical synthesis
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Summary:Artificial analogs of mycalamide A, a potent antitumor and antiviral compound isolated from a New Zealand marine sponge, were synthesized and their biological activities were tested. Artificial analogs of mycalamide A, a potent antitumor and antiviral compound isolated from a New Zealand marine sponge, were synthesized and their biological activities were tested.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00365-X