A case of multidrug resistant primary HIV infection with delayed CD4 T-cell count decline despite low viral load, treated with interleukin-2

• Published in: AIDS (London) Vol. 20; no. 11; pp. 1564 - 1565
• Main Authors: PAO, David, SMIT, Erasmus, IMAMI, Nesrina, FISHER, Martin
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 13.07.2006
• Subjects: Adult; Biological and medical sciences; CD4 Lymphocyte Count; Drug Resistance, Multiple, Viral; HIV Infections - drug therapy; HIV-1 - drug effects; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Interleukin-2 - therapeutic use; Male; Medical sciences; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Immunopathology; Primary infection; AIDS; Immune deficiency; Infection; Numeration; Microbiological investigation; Treatment; Interleukin 2; Immunological investigation; Viral disease; Multiple resistance; T-Lymphocyte; Viral load
• ISSN: 0269-9370; 1473-5571
• DOI: 10.1097/01.aids.0000237378.69433.6b

We report the clinical and laboratory features of an individual with recent multidrug resistant HIV-1 infection. The case is characterized by a high, stable CD4 cell count for 2 years followed by sudden, rapid decline despite the viral load being persistently < 1000 copies/ml. Further-more, treatment with interleukin-2, without antiretroviral drugs, has been successful in maintaining a robust CD4 T-cell cell count over 16 months.