Local Transplantation of G-CSF-Mobilized CD34+ Cells in a Patient with Tibial Nonunion: A Case Report

Although implantation of crude bone marrow cells has been applied in a small number of patients for fracture healing, transplantation of peripheral blood CD34+ cells, the hematopoietic/endothelial progenitor cell-enriched population, in patients with fracture has never been reported. Here, we report...

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Published inCell transplantation Vol. 20; no. 9; pp. 1491 - 1496
Main Authors Kuroda, Ryosuke, Matsumoto, Tomoyuki, Miwa, Masahiko, Kawamoto, Atsuhiko, Mifune, Yutaka, Fukui, Tomoaki, Kawakami, Yohei, Niikura, Takahiro, Lee, Sang Yang, Oe, Keisuke, Shoji, Taro, Kuroda, Tomoya, Horii, Miki, Yokoyama, Ayumi, Ono, Takayuki, Koibuchi, Yasushi, Kawamata, Shin, Fukushima, Masanori, Kurosaka, Masahiro, Asahara, Takayuki
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2011
SAGE Publishing
Subjects
Adult
Antigens, CD34 - metabolism
Fractures, Ununited - diagnostic imaging
Fractures, Ununited - therapy
Granulocyte Colony-Stimulating Factor - pharmacology
Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cell Transplantation
Humans
Male
Perioperative Care
Tibial Fractures - diagnostic imaging
Tibial Fractures - therapy
Tomography, X-Ray Computed
Tibial nonunion
Granulocyte colony stimulating factor (G-CSF)
Peripheral blood CD34+ cells
Online AccessGet full text

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Abstract Although implantation of crude bone marrow cells has been applied in a small number of patients for fracture healing, transplantation of peripheral blood CD34+ cells, the hematopoietic/endothelial progenitor cell-enriched population, in patients with fracture has never been reported. Here, we report the first case of tibial nonunion receiving autologous, granulocyte colony stimulating factor mobilized CD34+ cells accompanied with autologous bone grafting. No serious adverse event occurred, and the novel therapy performed 9 months after the primary operation resulted in bone union 3 months later without any symptoms including pain and gait disturbance.
AbstractList Although implantation of crude bone marrow cells has been applied in a small number of patients for fracture healing, transplantation of peripheral blood CD34(+) cells, the hematopoietic/endothelial progenitor cell-enriched population, in patients with fracture has never been reported. Here, we report the first case of tibial nonunion receiving autologous, granulocyte colony stimulating factor mobilized CD34(+) cells accompanied with autologous bone grafting. No serious adverse event occurred, and the novel therapy performed 9 months after the primary operation resulted in bone union 3 months later without any symptoms including pain and gait disturbance.
Although implantation of crude bone marrow cells has been applied in a small number of patients for fracture healing, transplantation of peripheral blood CD34 + cells, the hematopoietic/endothelial progenitor cell-enriched population, in patients with fracture has never been reported. Here, we report the first case of tibial nonunion receiving autologous, granulocyte colony stimulating factor mobilized CD34 + cells accompanied with autologous bone grafting. No serious adverse event occurred, and the novel therapy performed 9 months after the primary operation resulted in bone union 3 months later without any symptoms including pain and gait disturbance.
Author Fukui, Tomoaki
Koibuchi, Yasushi
Ono, Takayuki
Mifune, Yutaka
Shoji, Taro
Matsumoto, Tomoyuki
Lee, Sang Yang
Asahara, Takayuki
Kawakami, Yohei
Niikura, Takahiro
Kuroda, Ryosuke
Kurosaka, Masahiro
Fukushima, Masanori
Horii, Miki
Kawamoto, Atsuhiko
Yokoyama, Ayumi
Miwa, Masahiko
Kuroda, Tomoya
Kawamata, Shin
Oe, Keisuke
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Keywords Tibial nonunion
Granulocyte colony stimulating factor (G-CSF)
Peripheral blood CD34+ cells
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Snippet Although implantation of crude bone marrow cells has been applied in a small number of patients for fracture healing, transplantation of peripheral blood CD34+...
Although implantation of crude bone marrow cells has been applied in a small number of patients for fracture healing, transplantation of peripheral blood...
Although implantation of crude bone marrow cells has been applied in a small number of patients for fracture healing, transplantation of peripheral blood CD34...
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SubjectTerms Adult
Antigens, CD34 - metabolism
Fractures, Ununited - diagnostic imaging
Fractures, Ununited - therapy
Granulocyte Colony-Stimulating Factor - pharmacology
Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cell Transplantation
Humans
Male
Perioperative Care
Tibial Fractures - diagnostic imaging
Tibial Fractures - therapy
Tomography, X-Ray Computed
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Title Local Transplantation of G-CSF-Mobilized CD34+ Cells in a Patient with Tibial Nonunion: A Case Report
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