Local Transplantation of G-CSF-Mobilized CD34+ Cells in a Patient with Tibial Nonunion: A Case Report

• Published in: Cell transplantation Vol. 20; no. 9; pp. 1491 - 1496
• Main Authors: Kuroda, Ryosuke, Matsumoto, Tomoyuki, Miwa, Masahiko, Kawamoto, Atsuhiko, Mifune, Yutaka, Fukui, Tomoaki, Kawakami, Yohei, Niikura, Takahiro, Lee, Sang Yang, Oe, Keisuke, Shoji, Taro, Kuroda, Tomoya, Horii, Miki, Yokoyama, Ayumi, Ono, Takayuki, Koibuchi, Yasushi, Kawamata, Shin, Fukushima, Masanori, Kurosaka, Masahiro, Asahara, Takayuki
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2011; SAGE Publishing
• Subjects: Adult; Antigens, CD34 - metabolism; Fractures, Ununited - diagnostic imaging; Fractures, Ununited - therapy; Granulocyte Colony-Stimulating Factor - pharmacology; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Male; Perioperative Care; Tibial Fractures - diagnostic imaging; Tibial Fractures - therapy; Tomography, X-Ray Computed; Tibial nonunion; Granulocyte colony stimulating factor (G-CSF); Peripheral blood CD34+ cells
• ISSN: 0963-6897; 1555-3892
• DOI: 10.3727/096368910X550189

Although implantation of crude bone marrow cells has been applied in a small number of patients for fracture healing, transplantation of peripheral blood CD34+ cells, the hematopoietic/endothelial progenitor cell-enriched population, in patients with fracture has never been reported. Here, we report the first case of tibial nonunion receiving autologous, granulocyte colony stimulating factor mobilized CD34+ cells accompanied with autologous bone grafting. No serious adverse event occurred, and the novel therapy performed 9 months after the primary operation resulted in bone union 3 months later without any symptoms including pain and gait disturbance.