Prevention of Delayed Emesis Caused by Chemotherapy

To the Editor: In their article, the Italian Group for Antiemetic Research (May 25 issue) 1 did not give information about the mean number of vomiting episodes during days 2 through 5 in patients who had emesis; the times at which these episodes occurred in relation to the administration of oral ond...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 343; no. 12; pp. 888 - 890
Main Authors Copur, M S, Ledakis, P, Norvell, M
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 21.09.2000
Subjects
Administration, Oral
Antiemetics - administration & dosage
Antiemetics - pharmacokinetics
Antineoplastic Agents - adverse effects
Area Under Curve
Biological Availability
Dexamethasone - therapeutic use
Humans
Ondansetron - administration & dosage
Ondansetron - pharmacokinetics
Vomiting - chemically induced
Vomiting - prevention & control
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Summary:To the Editor: In their article, the Italian Group for Antiemetic Research (May 25 issue) 1 did not give information about the mean number of vomiting episodes during days 2 through 5 in patients who had emesis; the times at which these episodes occurred in relation to the administration of oral ondansetron, dexamethasone, or both; the median area under the curve for the plasma concentration of ondansetron; or the median maximal plasma concentration during the oral administration of drug on days 2 through 5. After the oral administration of ondansetron, the time until the peak concentration is reached varies from 0.5 . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM200009213431213