Predicting seizure frequency after epilepsy surgery

• Published in: Epilepsy research Vol. 67; no. 3; pp. 89 - 99
• Main Authors: Khoury, John S., Winokur, Ronald S., Tracy, Joseph I., Sperling, Michael R.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.2005; Elsevier
• Subjects: Adolescent; Adult; Age of first risk; Aging - physiology; Anterior Temporal Lobectomy; Anticonvulsants. Antiepileptics. Antiparkinson agents; Biological and medical sciences; Child; Child, Preschool; Craniocerebral Trauma - complications; Craniocerebral Trauma - epidemiology; Epilepsies, Partial - epidemiology; Epilepsy; Epilepsy - diagnostic imaging; Epilepsy - epidemiology; Epilepsy - pathology; Epilepsy - surgery; Epilepsy, Tonic-Clonic - epidemiology; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Infant; Intelligence Tests; Magnetic Resonance Imaging; Male; Medical sciences; Mesial temporal sclerosis; Middle Aged; Multivariate Analysis; Nervous system (semeiology, syndromes); Neurology; Neuropharmacology; Neurosurgical Procedures; Pharmacology. Drug treatments; Positron-Emission Tomography; Postoperative Period; Postoperative seizure frequency; Refractory seizures; Risk Factors; Sclerosis; Seizures - epidemiology; Seizures - pathology; Seizures, Febrile - epidemiology; Status Epilepticus - epidemiology; Temporal Lobe - pathology; Temporal Lobe - surgery; Mesial temporal sclerosis; Epilepsy surgery; Age of first risk; Refractory seizures; Epilepsy; Postoperative seizure frequency; Prognosis; Temporal lobectomy; Febrile convulsion; Subintrant crisis; Surgery; Neurological disorder; Status epilepticus; Human; Postoperative; Nervous system diseases; Decision making; Postoperative seizure frequency: Epilepsy surgery: Mesial temporal sclerosis; Recurrent; Nuclear magnetic resonance imaging; Morbidity; Cerebral disorder; Quality of life; Refractory; Temporal frequency; Clinical management; Central nervous system disease; Risk factor; Preoperative; Positron emission tomography; Positron; Emission tomography
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2005.09.005

To identify clinical features related to seizure frequency after epilepsy surgery in patients with recurrent seizures. No studies have examined the differences between patients who have rare seizures and patients who experience frequent seizures after epilepsy surgery. Since seizure frequency correlates with morbidity and quality of life, it is desirable to know which preoperative clinical features predict postoperative seizure frequency. Patients with recurrent seizures were placed in two categories: rare postoperative seizures (≤2 per year) and frequent postoperative seizures (≥12 per year) using seizure frequency in the second postoperative year. Variables included preoperative seizure frequency, age of first risk, age at first seizure, epilepsy duration, age at surgery, history of febrile convulsions, tonic-clonic seizures, status epilepticus, or family history, IQ, magnetic resonance imaging (MRI), and positron emission tomography (PET). Variables were analyzed using non-parametric tests to assess relationship to postoperative seizure frequency. Of 475 patients who had epilepsy surgery, 111 had rare or frequent seizures in the second postoperative year. After anterior temporal lobectomy (ATL), age of first risk ≤ 5 years and presence of mesial temporal sclerosis on MRI were associated with rare seizures (66% of patients), whereas lack of these risk factors was associated with frequent seizures (75% of patients) ( p < 0.03). For non-ATL operations, preoperative seizure frequency of ≥20 seizures per month was associated with frequent postoperative seizures ( p = 0.03). No other variables influenced outcome. Some preoperative clinical features correlate with postoperative seizure frequency in patients with recurrent seizures after epilepsy surgery. This has implications for the surgical decision making process and early postoperative management.