Complete recovery of pyoderma gangrenosum after successful treatment of underlying hairy cell leukemia with cladribine

• Published in: The Korean journal of internal medicine Vol. 30; no. 5; pp. 739 - 741
• Main Authors: Tombak, Anıl, Aygün, Sinan, Serinsöz, Ebru, Tiftik, Eyüp Naci
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Association of Internal Medicine 01.09.2015; 대한내과학회
• Subjects: Adult; Antineoplastic Agents - therapeutic use; Biopsy; Cladribine - therapeutic use; Humans; Letter to the Editor; Leukemia, Hairy Cell - complications; Leukemia, Hairy Cell - diagnosis; Leukemia, Hairy Cell - drug therapy; Male; Pyoderma Gangrenosum - diagnosis; Pyoderma Gangrenosum - etiology; Remission Induction; Time Factors; Treatment Outcome; 내과학; Leukemia, hairy cell; Cladribine; Pyoderma gangrenosum
• ISSN: 1226-3303; 2005-6648
• DOI: 10.3904/kjim.2015.30.5.739

symptoms of PG [3-5]. Patients presenting with PG should be carefully examined for an underlying hematological malignancy with detailed anamnesis, a physical examination, and laboratory testing. HCL can be easily diagnosed in patients with pancytopenia, splenomegaly, and typical hairy cells, and skin ulcers can be related to PG, as in our patient. Although the histopathological changes are not specific to PG, biopsies of the lesions must be performed, as these lesions can also be related to infiltration of leukemic cells. Once HCL and PG are diagnosed, the main treatment target should be HCL, as PG will completely recover in a few months with the successful treatment of HCL using cladribine, as in our patient. KCI Citation Count: 1