Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer
Liver cancer epidemiology is changing due to increasing alcohol consumption, rising prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) treatment. However, the impact of these changes on global liver cancer burden remains unclear. We estimated global and region...
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| Published in | Cell metabolism Vol. 34; no. 7; pp. 969 - 977.e2 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
05.07.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Liver cancer epidemiology is changing due to increasing alcohol consumption, rising prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) treatment. However, the impact of these changes on global liver cancer burden remains unclear. We estimated global and regional temporal trends in the burden of liver cancer and the contributions of various liver disease etiologies using the methodology framework of the Global Burden of Disease study. Between 2010 and 2019, there was a 25% increase in liver cancer deaths. Age-standardized death rates (ASDRs) increased only in the Americas and remained stable or fell in all other regions. Between 2010 and 2019, non-alcoholic steatohepatitis (NASH) and alcohol had the fastest growing ASDRs, while HCV and HBV declined. Urgent measures are required at a global level to tackle underlying metabolic risk factors and slow the growing burden of NASH-associated liver cancer, especially in the Americas. |
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| AbstractList | Liver cancer epidemiology is changing due to increasing alcohol consumption, rising prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) treatment. However, the impact of these changes on global liver cancer burden remains unclear. We estimated global and regional temporal trends in the burden of liver cancer and the contributions of various liver disease etiologies using the methodology framework of the Global Burden of Disease study. Between 2010 and 2019, there was a 25% increase in liver cancer deaths. Age-standardized death rates (ASDRs) increased only in the Americas and remained stable or fell in all other regions. Between 2010 and 2019, non-alcoholic steatohepatitis (NASH) and alcohol had the fastest growing ASDRs, while HCV and HBV declined. Urgent measures are required at a global level to tackle underlying metabolic risk factors and slow the growing burden of NASH-associated liver cancer, especially in the Americas. Liver cancer epidemiology is changing due to increasing alcohol consumption, rising prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) treatment. However, the impact of these changes on global liver cancer burden remains unclear. We estimated global and regional temporal trends in the burden of liver cancer and the contributions of various liver disease etiologies using the methodology framework of the Global Burden of Disease study. Between 2010 and 2019, there was a 25% increase in liver cancer deaths. Age-standardized death rates (ASDRs) increased only in the Americas and remained stable or fell in all other regions. Between 2010 and 2019, non-alcoholic steatohepatitis (NASH) and alcohol had the fastest growing ASDRs, while HCV and HBV declined. Urgent measures are required at a global level to tackle underlying metabolic risk factors and slow the growing burden of NASH-associated liver cancer, especially in the Americas. Huang et al. estimate global and regional trends in the burden of liver cancer and the contributions of various liver disease etiologies from 2010 to 2019. They determined that NASH was the fastest growing cause of age-adjusted liver cancer deaths globally, while age-adjusted deaths from hepatitis B and C declined. |
| Author | El-Serag, Hashem B Tan, Darren J H Singal, Amit G Huang, Daniel Q Loomba, Rohit Kono, Yuko |
| AuthorAffiliation | 5 Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA 7 Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA 3 Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore, Singapore 8 Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX, USA 10 Lead contact 2 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 9 Division of Epidemiology, Department of Family Medicine and Public Health, University of California, San Diego, San Diego, CA, USA 4 Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX, USA 1 NAFLD Research Center, Division of Gastroenterology, University of California, San Diego, La Jolla, CA, USA 6 Section of Gastroenterology and Hepatolo |
| AuthorAffiliation_xml | – name: 5 Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA – name: 3 Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore, Singapore – name: 9 Division of Epidemiology, Department of Family Medicine and Public Health, University of California, San Diego, San Diego, CA, USA – name: 2 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore – name: 10 Lead contact – name: 6 Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA – name: 4 Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX, USA – name: 8 Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX, USA – name: 7 Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA – name: 1 NAFLD Research Center, Division of Gastroenterology, University of California, San Diego, La Jolla, CA, USA |
| Author_xml | – sequence: 1 givenname: Daniel Q surname: Huang fullname: Huang, Daniel Q organization: NAFLD Research Center, Division of Gastroenterology, University of California, San Diego, La Jolla, CA, USA; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore, Singapore – sequence: 2 givenname: Amit G surname: Singal fullname: Singal, Amit G organization: Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX, USA – sequence: 3 givenname: Yuko surname: Kono fullname: Kono, Yuko organization: Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA – sequence: 4 givenname: Darren J H surname: Tan fullname: Tan, Darren J H organization: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore – sequence: 5 givenname: Hashem B surname: El-Serag fullname: El-Serag, Hashem B organization: Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA; Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA; Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX, USA – sequence: 6 givenname: Rohit surname: Loomba fullname: Loomba, Rohit email: roloomba@ucsd.edu organization: NAFLD Research Center, Division of Gastroenterology, University of California, San Diego, La Jolla, CA, USA; Division of Epidemiology, Department of Family Medicine and Public Health, University of California, San Diego, San Diego, CA, USA. Electronic address: roloomba@ucsd.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35793659$$D View this record in MEDLINE/PubMed |
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| Title | Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer |
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