Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer

Liver cancer epidemiology is changing due to increasing alcohol consumption, rising prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) treatment. However, the impact of these changes on global liver cancer burden remains unclear. We estimated global and region...

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Published inCell metabolism Vol. 34; no. 7; pp. 969 - 977.e2
Main Authors Huang, Daniel Q, Singal, Amit G, Kono, Yuko, Tan, Darren J H, El-Serag, Hashem B, Loomba, Rohit
Format Journal Article
LanguageEnglish
Published United States 05.07.2022
Subjects
Hepatitis C - complications
Humans
Liver Neoplasms - epidemiology
Liver Neoplasms - etiology
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - epidemiology
Obesity - complications
Obesity - epidemiology
Risk Factors
United States
United States
alcohol
nonalcoholic steatohepatitis
epidemiology
hepatitis B
hepatitis C
hepatoma
liver cancer
hepatocellular carcinoma
etiology
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Summary:Liver cancer epidemiology is changing due to increasing alcohol consumption, rising prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) treatment. However, the impact of these changes on global liver cancer burden remains unclear. We estimated global and regional temporal trends in the burden of liver cancer and the contributions of various liver disease etiologies using the methodology framework of the Global Burden of Disease study. Between 2010 and 2019, there was a 25% increase in liver cancer deaths. Age-standardized death rates (ASDRs) increased only in the Americas and remained stable or fell in all other regions. Between 2010 and 2019, non-alcoholic steatohepatitis (NASH) and alcohol had the fastest growing ASDRs, while HCV and HBV declined. Urgent measures are required at a global level to tackle underlying metabolic risk factors and slow the growing burden of NASH-associated liver cancer, especially in the Americas.
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Study design, D.Q.H. and R.L.; data acquisition, D.Q.H. and D.J.H.T.; data analysis and verification, D.Q.H. and D.J.H.T.; data interpretation, all authors; original draft, D.Q.H.; revision of the manuscript, all authors; study concept and study supervision, D.Q.H. and R.L. All authors had access to the data and approved the final draft of the manuscript as well as the author list.
AUTHOR CONTRIBUTIONS
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2022.05.003