Translation‐coupled mRNA quality control mechanisms

mRNA surveillance pathways are essential for accurate gene expression and to maintain translation homeostasis, ensuring the production of fully functional proteins. Future insights into mRNA quality control pathways will enable us to understand how cellular mRNA levels are controlled, how defective...

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Bibliographic Details
Published inThe EMBO journal Vol. 42; no. 19; p. e114378
Main Authors Monaghan, Laura, Longman, Dasa, Cáceres, Javier F
Format Journal Article
LanguageEnglish
Published Heidelberg Blackwell Publishing Ltd 04.10.2023
John Wiley and Sons Inc
Subjects
Decay
Gene expression
Homeostasis
mRNA turnover
Nonsense-mediated mRNA decay
Quality control
Review
Translation
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Summary:mRNA surveillance pathways are essential for accurate gene expression and to maintain translation homeostasis, ensuring the production of fully functional proteins. Future insights into mRNA quality control pathways will enable us to understand how cellular mRNA levels are controlled, how defective or unwanted mRNAs can be eliminated, and how dysregulation of these can contribute to human disease. Here we review translation‐coupled mRNA quality control mechanisms, including the non‐stop and no‐go mRNA decay pathways, describing their mechanisms, shared trans‐acting factors, and differences. We also describe advances in our understanding of the nonsense‐mediated mRNA decay (NMD) pathway, highlighting recent mechanistic findings, the discovery of novel factors, as well as the role of NMD in cellular physiology and its impact on human disease.
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ISSN:0261-4189
1460-2075
DOI:10.15252/embj.2023114378