Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders

• Published in: Journal of Neural Transmission Vol. 117; no. 9; pp. 1119 - 1122
• Main Authors: Takebayashi, M., Hashimoto, R., Hisaoka, K., Tsuchioka, M., Kunugi, H.
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.09.2010; Springer Nature B.V
• Subjects: Adult; Aged; Analysis of Variance; Biological Psychiatry - Short Communication; Depressive Disorder, Major - blood; Enzyme-Linked Immunosorbent Assay; Female; Fibroblast Growth Factor 2 - blood; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Neurology; Neurosciences; Psychiatry; Vascular Endothelial Growth Factor A - blood; Mood disorders; FGF-2; Plasma; Family history; VEGF
• ISSN: 0300-9564; 1435-1463; 1435-1463
• DOI: 10.1007/s00702-010-0452-1

We investigated the plasma levels of VEGF and FGF-2, important factors for regulation of neuroplasticity such as neurogenesis, in patients in remission from major depressive disorders (MDD). The plasma VEGF levels were significantly higher in the MDD patients than in the matched control subjects, while no significant difference in plasma FGF-2 levels was found. In particular, the MDD patients with family history of psychiatric disorders, but not patients without such a family history, showed significantly higher values of plasma VEGF than the controls. Although this is a preliminary study, altered VEGF levels might be involved in the pathophysiology of MDD.