The impact of non-motor symptoms on the health-related quality of life in patients with functional movement disorders

• Published in: Journal of psychosomatic research Vol. 115; pp. 32 - 37
• Main Authors: Věchetová, Gabriela, Slovák, Matěj, Kemlink, David, Hanzlíková, Zuzana, Dušek, Pavel, Nikolai, Tomáš, Růžička, Evžen, Edwards, Mark J., Serranová, Tereza
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.12.2018; Elsevier Science Ltd
• Subjects: Anxiety; Apathy; Cognitive ability; Cognitive skills; Complaints; Emotional behavior; Fatigue; Five factor model; Functional movement disorder; Health status; Health-related quality of life; Humans; Male; Medical disorders; Mental depression; Middle Aged; Motor ability; Movement; Movement disorders; Movement Disorders - diagnosis; Movement Disorders - psychology; Multiple regression analysis; Multiple symptoms; Neurosis; Neuroticism; Non-motor symptoms; Pain; Patients; Personality; Personality traits; Quality of life; Quality of Life - psychology; Questionnaires; Regression analysis; Severity; Sleep and wakefulness; Sleepiness; Symptoms; Trait anxiety; Health-related quality of life; Non-motor symptoms; Functional movement disorder; Personality traits
• ISSN: 0022-3999; 1879-1360
• DOI: 10.1016/j.jpsychores.2018.10.001

Pain, fatigue, cognitive complaints and psychiatric comorbidities are common in patients with functional movement disorder and may significantly affect their quality of life. The aim of the study was to assess the impact of motor and non-motor symptoms on health-related quality of life in patients with functional movement disorder. Sixty-one patients with clinically established functional movement disorder and 61 matched healthy controls completed standardized questionnaires for depression, anxiety, cognitive complaints, fatigue, pain, sleepiness, apathy and health-related quality of life. Motor disorder severity was assessed using The Simplified Functional Movement Disorders Rating Scale. Personality traits were assessed using the 44-Item Big Five Inventory. Compared to controls, patients reported significantly lower health-related quality of life and higher levels of all assessed non-motor symptoms except for apathy. No difference was found in personality traits. In both groups, health-related quality of life scores negatively correlated with depression, anxiety, pain, cognitive complaints, apathy, and neuroticism. No correlation was found between health-related quality of life and motor symptom severity in patients with functional movement disorder. Multiple regression analysis of the predictors of health-related quality of life showed significant impact of trait anxiety and cognitive complaints scores. Multiple non-motor symptoms but not motor symptom severity correlated with impaired health-related quality of life in patients with functional movement disorder. Impaired health-related quality of life was predicted by anxiety and cognitive complaints. Our results highlight the importance of assessing and treating both motor and non-motor symptoms in patients with functional movement disorder. •Health-related quality of life is impaired in FMD compared to controls.•Non-motor symptoms are more frequent in FMD compared to controls.•Non-motor symptoms and neuroticism correlate with health-related quality of life.•Motor symptoms severity doesn't correlate with health-related quality of life in FMD.•Anxiety and cognitive complaints predict worse health-related quality of life in FMD.