Persistent intrathecal secretion of oligoclonal, Borrelia burgdorferi-specific IgG in chronic meningoradiculomyelitis

In the cerebrospinal fluid IgG of five patients with lymphomeningoradiculitis (Bannwarth's syndrome) and radiculomyelitis studied by immunoblot technique an oligoclonal pattern was found. Most of these oligoclonal bands were specific for Borrelia burgdorferi. In patients suffering from chronic...

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Bibliographic Details
Published inJournal of neurology Vol. 235; no. 4; p. 229
Main Authors Martin, R, Martens, U, Sticht-Groh, V, Dörries, R, Krüger, H
Format Journal Article
LanguageEnglish
Published Germany 01.03.1988
Subjects
Antibodies, Bacterial - analysis
Antibody Formation
Borrelia - immunology
Chronic Disease
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin G - analysis
Immunoglobulin G - biosynthesis
Lyme Disease - diagnosis
Lyme Disease - immunology
Meningitis - diagnosis
Meningitis - immunology
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Summary:In the cerebrospinal fluid IgG of five patients with lymphomeningoradiculitis (Bannwarth's syndrome) and radiculomyelitis studied by immunoblot technique an oligoclonal pattern was found. Most of these oligoclonal bands were specific for Borrelia burgdorferi. In patients suffering from chronic meningoradiculomyelitis, repeated CSF examination by this technique showed persistent secretion of identical IgG bands. Thus, the specific humoral immune response and the disease activity could be documented over the course of the disease.
ISSN:0340-5354
DOI:10.1007/BF00314352