Quantitative and high drug loading of self-assembled prodrug with defined molecular structures for effective cancer therapy
Nanomedicines have made significant progress in the delivery of small molecular drugs, many challenges, however, still remain to be overcome, such as unsatisfactory drug loading, formulation instability, premature drug leakage, and poor blood circulation. Herein, an innovative glutathione (GSH)-sens...
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Published in | Journal of controlled release Vol. 307; pp. 90 - 97 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
10.08.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Nanomedicines have made significant progress in the delivery of small molecular drugs, many challenges, however, still remain to be overcome, such as unsatisfactory drug loading, formulation instability, premature drug leakage, and poor blood circulation. Herein, an innovative glutathione (GSH)-sensitive amphiphilic dendritic prodrug with quantitative and high drug loading (>30 wt%) is reported. The multi-armed structure of prepared prodrug can self-assemble into nanoparticles in aqueous solution without the introduction of any organic solvents. The self-assembled prodrug nanoparticle is composed of the following key components: (i) polyethylene glycol (PEG) outer shell ensuring biocompatibility and prolonging blood circulation, (ii) prodrug inner core responding to GSH for triggered release of intact drug, (iii) multi-armed dendritic structure facilitating self-assembly and enhancing drug loading content, (iv) covalent drug conjugation avoiding drug leakage and improving stability, (v) defined chemical structures and quantitative drug loading easy for reproduction. Both in vitro and in vivo results show that these GSH-responsive prodrug nanoparticle exhibits significant inhibition of tumor cell growth, and is promising for efficient and safe chemotherapeutic delivery.
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0168-3659 1873-4995 |
DOI: | 10.1016/j.jconrel.2019.06.010 |