A Personalised Dietary Approach-A Way Forward to Manage Nutrient Deficiency, Effects of the Western Diet, and Food Intolerances in Inflammatory Bowel Disease

• Published in: Nutrients Vol. 11; no. 7; p. 1532
• Main Authors: Laing, Bobbi B, Lim, Anecita Gigi, Ferguson, Lynnette R
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.07.2019; MDPI
• Subjects: Adolescent; Adolescent Nutritional Physiological Phenomena; Adult; Animals; brassica; Child; Child Nutritional Physiological Phenomena; Deficiency Diseases - diet therapy; Deficiency Diseases - epidemiology; Deficiency Diseases - genetics; Deficiency Diseases - physiopathology; Diet, Western - adverse effects; Feeding Behavior; Female; FODMAPs; Food Hypersensitivity - diet therapy; Food Hypersensitivity - epidemiology; Food Hypersensitivity - genetics; Food Hypersensitivity - physiopathology; food intolerance; fructose; Gene-Environment Interaction; genotypes; gluten; Humans; Inflammatory bowel disease; Inflammatory Bowel Diseases - diet therapy; Inflammatory Bowel Diseases - epidemiology; Inflammatory Bowel Diseases - genetics; Inflammatory Bowel Diseases - physiopathology; lactose; Male; Middle Aged; mushrooms; nutrient deficiency; Nutrigenomics - methods; Nutritional Status - genetics; Nutritive Value; Precision Medicine - methods; Review; Risk Factors; Treatment Outcome; Westernisation; Young Adult; mushrooms; gluten; Westernisation; FODMAPs; food intolerance; genotypes; fructose; lactose; brassica; nutrient deficiency; inflammatory bowel disease
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu11071532

This review discusses the personalised dietary approach with respect to inflammatory bowel disease (IBD). It identifies gene-nutrient interactions associated with the nutritional deficiencies that people with IBD commonly experience, and the role of the Western diet in influencing these. It also discusses food intolerances and how particular genotypes can affect these. It is well established that with respect to food there is no "one size fits all" diet for those with IBD. Gene-nutrient interactions may help explain this variability in response to food that is associated with IBD. Nutrigenomic research, which examines the effects of food and its constituents on gene expression, shows that-like a number of pharmaceutical products-food can have beneficial effects or have adverse (side) effects depending on a person's genotype. Pharmacogenetic research is identifying gene variants with adverse reactions to drugs, and this is modifying clinical practice and allowing individualised treatment. Nutrigenomic research could enable individualised treatment in persons with IBD and enable more accurate tailoring of food intake, to avoid exacerbating malnutrition and to counter some of the adverse effects of the Western diet. It may also help to establish the dietary pattern that is most protective against IBD.