Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice

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Bibliographic Details
Published inArteriosclerosis, thrombosis, and vascular biology Vol. 41; no. 5; pp. 1694 - 1709
Main Authors Muniappan, Latha, Okuyama, Michihiro, Javidan, Aida, Thiagarajan, Devi, Jiang, Weihua, Moorleghen, Jessica J, Yang, Lihua, Balakrishnan, Anju, Howatt, Deborah A, Uchida, Haruhito A, Saido, Takaomi C, Subramanian, Venkateswaran
Format Journal Article
LanguageEnglish
Published United States 05.05.2021
Subjects
Aged
Aged, 80 and over
Angiotensin II
Animals
Aorta, Abdominal - enzymology
Aorta, Abdominal - pathology
Aortic Aneurysm, Abdominal - chemically induced
Aortic Aneurysm, Abdominal - enzymology
Aortic Aneurysm, Abdominal - genetics
Aortic Aneurysm, Abdominal - prevention & control
Aortic Rupture - chemically induced
Aortic Rupture - enzymology
Aortic Rupture - genetics
Aortic Rupture - prevention & control
Calpain - deficiency
Calpain - genetics
Calpain - metabolism
Cells, Cultured
Cytoskeleton - enzymology
Cytoskeleton - pathology
Dilatation, Pathologic
Disease Models, Animal
Extracellular Matrix - enzymology
Extracellular Matrix - pathology
Female
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Middle Aged
Rats
Receptors, LDL - deficiency
Receptors, LDL - genetics
Vascular Remodeling
calpain
cytoskeletal protein
filamin A
angiotensin II
tamoxifen
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Summary:[Figure: see text].
Bibliography:Deceased
Joint co-first authors.
ISSN:1079-5642
1524-4636
DOI:10.1161/ATVBAHA.120.315546