Mangiferin decreases inflammation and oxidative damage in rat brain after stress

• Published in: European journal of nutrition Vol. 51; no. 6; pp. 729 - 739
• Main Authors: Márquez, Lucía, García-Bueno, Borja, Madrigal, José L. M., Leza, Juan C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.09.2012; Springer; Springer Nature B.V
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Antioxidants - administration & dosage; Antioxidants - therapeutic use; Biological and medical sciences; Brain - drug effects; Brain - immunology; Brain - metabolism; Chemistry; Chemistry and Materials Science; Corticosterone - blood; Cyclooxygenase 2 - metabolism; Dose-Response Relationship, Drug; Ethnopharmacology; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Inflammation Mediators - blood; Inflammation Mediators - metabolism; Lipid Peroxidation - drug effects; Male; Nerve Tissue Proteins - metabolism; Neurons - drug effects; Neurons - immunology; Neurons - metabolism; Neuroprotective Agents - administration & dosage; Neuroprotective Agents - therapeutic use; Nitric Oxide Synthase Type II - metabolism; Nutrition; Original Contribution; Oxidative Stress - drug effects; Random Allocation; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor, Type I - metabolism; Stress, Psychological - blood; Stress, Psychological - drug therapy; Stress, Psychological - immunology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Xanthones - administration & dosage; Xanthones - therapeutic use; Polyphenols; Neuroinflammation; Oxidative/nitrosative damage; Mangiferin; Stress; Nutrition; Rat; Rodentia; Central nervous system; Inflammation; Encephalon; Micronutrient; Vertebrata; Polyphenol; Mammalia; Decrease; Animal; Proanthocyanidin
• ISSN: 1436-6207; 1436-6215
• DOI: 10.1007/s00394-011-0252-x

Purpose Stress exposure elicits neuroinflammation and oxidative damage in brain, and stress-related neurological and neuropsychiatric diseases have been associated with cell damage and death. Mangiferin (MAG) is a polyphenolic compound abundant in the stem bark of Mangifera indica L. with antioxidant and anti-inflammatory properties in different experimental settings. In this study, the capacity of MAG to prevent neuroinflammation and brain oxidative damage induced by stress exposure was investigated. Methods Young–adult male Wistar rats immobilized during 6 h were administered by oral gavage with increasing doses of MAG (15, 30, and 60 mg/Kg), respectively, 7 days before stress. Results Prior treatment with MAG prevented all of the following stress-induced effects: (1) increase in glucocorticoids (GCs) and interleukin-1β (IL-1β) plasma levels, (2) loss of redox balance and reduction in catalase brain levels, (3) increase in pro-inflammatory mediators, such as tumor necrosis factor alpha TNF-α and its receptor TNF-R1, nuclear factor-kappa B (NF-κB) and synthesis enzymes, such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), (4) increase in lipid peroxidation. Conclusions These multifaceted protective effects suggest that MAG administration could be a new therapeutic strategy in neurological/neuropsychiatric pathologies in which hypothalamic/pituitary/adrenal (HPA) stress axis dysregulation, neuroinflammation, and oxidative damage take place in their pathophysiology.