Circumdatin H, a new inhibitor of mitochondrial NADH oxidase, from Aspergillus ochraceus

• Published in: Journal of antibiotics Vol. 58; no. 6; pp. 416 - 419
• Main Authors: Lopez-Gresa, MP, Gonzalez, MC, Primo, J, Moya, P, Romero, Estornell, E
• Format: Journal Article
• Language: English
• Published: TOKYO Japan Antibiotics Research Assoc 01.06.2005; Nature Publishing Group
• Subjects: Aspergillus ochraceus - metabolism; Benzodiazepinones - isolation & purification; Benzodiazepinones - pharmacology; Biotechnology & Applied Microbiology; Chemical Phenomena; Chemistry, Physical; Electron Transport - drug effects; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - pharmacology; Fermentation; Immunology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microbiology; Mitochondria - drug effects; Mitochondria - enzymology; Multienzyme Complexes - antagonists & inhibitors; NADH, NADPH Oxidoreductases - antagonists & inhibitors; Pharmacology & Pharmacy; Science & Technology; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Aspergillus ochraceus; flavacol; stephacidin A; RESPIRATORY-CHAIN; ANALOGS; COMPLEX I INHIBITORS; alkaloids; OXIDOREDUCTASE; mitochondrial respiratory chain inhibitors; circumdatin; benzodiazepine
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/ja.2005.54

Circumdatin H (1), a new alkaloid from the culture broth of Aspergillus ochraceus, has been isolated, together with a known circumdatin, circumdatin E (2) and other known compounds: flavacol (3) and stephacidin A (4). The structure of 1 was established on the basis of chemical and spectral evidence. All of these alkaloids showed biological activity as inhibitors of the mammalian mitochondrial respiratory chain.