Phytochemical investigation on Vitex negundo leaves and their anti-inflammatory and analgesic activities
Abstract The phytochemical investigation on Vitex negundo leaves has led to the isolation of one new iridoid glucoside (8α-hydroxy-4-carboxyl-5βH-9βH-iridoid-1α-O-(6′-O-(6,7-dihydrofoliamenthonyl)-β-ᴅ-glucopyranoside, 3), together with three known compounds, namely agnuside (1), 6′-O-E-caffeoylmussa...
Saved in:
| Published in | Brazilian Journal of Pharmaceutical Sciences Vol. 58 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
01.01.2022
Universidade de São Paulo |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Abstract The phytochemical investigation on Vitex negundo leaves has led to the isolation of one new iridoid glucoside (8α-hydroxy-4-carboxyl-5βH-9βH-iridoid-1α-O-(6′-O-(6,7-dihydrofoliamenthonyl)-β-ᴅ-glucopyranoside, 3), together with three known compounds, namely agnuside (1), 6′-O-E-caffeoylmussaenosidic acid (2), and 3,5-dicaffeoylquinic acid (4). The HPLC analytical study was also performed to quantify the content of agnuside (1) in dried leaves. The results indicated the very high content of 1 (3.04 ± 0.02%). The method was also validated by various parameters, including linearity (R2= 0.9999), precision (intra-day RSD ≤ 2.50%, inter-day RSD= 0.76%), and accuracy (recovery rates 96.58-101.86%). The animal testing data showed that the extract did not reduce pain at the doses of 9.6 and 28.8 g /kg (leaf weight/body weight) in the hot plates and pain measuring models but showed the pain reduction in the acetic acid-induced pain model. The extract at the dose of 5.6 g/kg (leaf weight/body weight) also had effects on the acute inflammation in the carrageenin-induced edema model. The extract at the dose 9.6 and 28.8 g/kg (leaf weight/body weight) also showed significant chronic anti-inflammation, comparable to methylprednisolone at the dose 10 mg/kg on the mouse peritoneal. |
|---|---|
| AbstractList | Abstract The phytochemical investigation on Vitex negundo leaves has led to the isolation of one new iridoid glucoside (8α-hydroxy-4-carboxyl-5βH-9βH-iridoid-1α-O-(6′-O-(6,7-dihydrofoliamenthonyl)-β-ᴅ-glucopyranoside, 3), together with three known compounds, namely agnuside (1), 6′-O-E-caffeoylmussaenosidic acid (2), and 3,5-dicaffeoylquinic acid (4). The HPLC analytical study was also performed to quantify the content of agnuside (1) in dried leaves. The results indicated the very high content of 1 (3.04 ± 0.02%). The method was also validated by various parameters, including linearity (R2= 0.9999), precision (intra-day RSD ≤ 2.50%, inter-day RSD= 0.76%), and accuracy (recovery rates 96.58-101.86%). The animal testing data showed that the extract did not reduce pain at the doses of 9.6 and 28.8 g /kg (leaf weight/body weight) in the hot plates and pain measuring models but showed the pain reduction in the acetic acid-induced pain model. The extract at the dose of 5.6 g/kg (leaf weight/body weight) also had effects on the acute inflammation in the carrageenin-induced edema model. The extract at the dose 9.6 and 28.8 g/kg (leaf weight/body weight) also showed significant chronic anti-inflammation, comparable to methylprednisolone at the dose 10 mg/kg on the mouse peritoneal. |
| Author | Nguyen, Trang Tuyet Nguyen, Lan Ngoc Thi Nguyen, Tu Thanh Thi Do, Phuong Thi Pham, Anh Van Thi Nguyen, Huong Giang Thi Tran |
| AuthorAffiliation | Hanoi Medical University |
| AuthorAffiliation_xml | – name: Hanoi Medical University |
| Author_xml | – sequence: 1 givenname: Tu Thanh Thi orcidid: 0000-0002-8668-3126 surname: Nguyen fullname: Nguyen, Tu Thanh Thi organization: Hanoi Medical University, Vietnam – sequence: 2 givenname: Phuong Thi surname: Do fullname: Do, Phuong Thi organization: Hanoi Medical University, Vietnam – sequence: 3 givenname: Anh Van Thi surname: Pham fullname: Pham, Anh Van Thi organization: Hanoi Medical University, Vietnam – sequence: 4 givenname: Huong Giang Thi Tran surname: Nguyen fullname: Nguyen, Huong Giang Thi Tran organization: Hanoi Medical University, Vietnam – sequence: 5 givenname: Lan Ngoc Thi surname: Nguyen fullname: Nguyen, Lan Ngoc Thi organization: Hanoi Medical University, Vietnam – sequence: 6 givenname: Trang Tuyet surname: Nguyen fullname: Nguyen, Trang Tuyet organization: Hanoi Medical University, Vietnam |
| BookMark | eNpVUdtqGzEQFSWBuIn_IA_7A-vqupIei2nTQCCFXl7FrHbWlllLRVJC_Pdd28WkMDCHOZzDzJyP5CqmiITcM7piytJPhTOtWqst5ZRzZFZ24gNZXKZX7_ANWZayo5QyJY2VakG237eHmvwW98HD1IT4iqWGDdSQYjPX71DxrYm4eYlDaiaEmW8gDk3dYsgzqqENcZxgv4ea8uHEQYRpgyX4BnwNr6EGLHfkeoSp4PJfvyW_vn75uf7WPj0_PK4_P7VeUl7bTgy040xo46G3xmsuNfWmw9FqmCkzStoNnVGAhkoruBGSGdMbJlUvRS9uyePZd0iwc39y2EM-uATBnQYpbxzkGvyEjot-0Nzy0aKQPQqjO9V7PUqrmKLWzl6rs1fxAafkduklz6cV94NZI53h6vTz4z8p7ayZBfIs8DmVknG8LMCoO6blTmm5_9MSfwFHg4dp |
| CitedBy_id | crossref_primary_10_1007_s13530_024_00214_y |
| Cites_doi | 10.1016/j.fitote.2016.04.020 10.1016/j.fitote.2015.03.001 10.1007/s11033-018-4421-3 10.1016/0014-2999(74)90195-2 10.1007/s00011-011-0410-x 10.1016/j.jff.2017.05.047 10.1016/S0378-8741(03)00159-4 10.3181/00379727-111-27849 10.4103/0974-8490.99072 10.1055/s-2006-957638 10.1271/bbb.100279 10.1016/j.fitote.2019.104265 10.1021/acs.jnatprod.6b01189 10.1248/cpb.46.655 10.1055/s-2006-961411 10.1016/j.jep.2015.06.045 10.1055/s-2002-20048 10.1021/np500509q 10.6026/97320630007199 10.1002/ptr.5303 10.4103/0250-474X.49140 |
| ContentType | Journal Article |
| Copyright | This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Copyright_xml | – notice: This work is licensed under a Creative Commons Attribution 4.0 International License. |
| DBID | AAYXX CITATION GPN DOA |
| DOI | 10.1590/s2175-97902022e19463 |
| DatabaseName | CrossRef SciELO DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 2175-9790 |
| ExternalDocumentID | oai_doaj_org_article_23bd7292f9e34be38765bc7f49515099 S1984_82502022000100698 10_1590_s2175_97902022e19463 |
| GroupedDBID | --- 5VS 7X7 8FI 8FJ AAYXX ABUWG ABXHO ADBBV AENEX AFKRA ALIPV ALMA_UNASSIGNED_HOLDINGS APOWU AZFZN BAWUL BCNDV BENPR CCPQU CITATION DIK DU5 FYUFA GROUPED_DOAJ GX1 HMCUK IPNFZ KQ8 M~E OK1 PIMPY RIG RSC SCD UKHRP GPN |
| ID | FETCH-LOGICAL-c402t-63d0621378cab98c72470c86ef97ad068f406d685ae804932834188b8145b43b3 |
| IEDL.DBID | DOA |
| ISSN | 2175-9790 |
| IngestDate | Tue Oct 22 15:09:49 EDT 2024 Fri Oct 18 21:43:32 EDT 2024 Fri Aug 23 01:26:37 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Iridoid Analgesic Anti-inflammatory Vitex negundo HPLC quantification |
| Language | English |
| License | This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c402t-63d0621378cab98c72470c86ef97ad068f406d685ae804932834188b8145b43b3 |
| ORCID | 0000-0002-8668-3126 |
| OpenAccessLink | https://doaj.org/article/23bd7292f9e34be38765bc7f49515099 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_23bd7292f9e34be38765bc7f49515099 scielo_journals_S1984_82502022000100698 crossref_primary_10_1590_s2175_97902022e19463 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-01-01 |
| PublicationDateYYYYMMDD | 2022-01-01 |
| PublicationDate_xml | – month: 01 year: 2022 text: 2022-01-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationTitle | Brazilian Journal of Pharmaceutical Sciences |
| PublicationTitleAlternate | Braz. J. Pharm. Sci |
| PublicationYear | 2022 |
| Publisher | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas Universidade de São Paulo |
| Publisher_xml | – name: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas – name: Universidade de São Paulo |
| References | Kulkarni RR (ref12) 2008; 70 Singh DD (ref19) 2005; 44 (ref15) 2006 Baghdikian B (ref2) 1997; 63 (ref10) 2005 Gupta RK (ref7) 2005; 49 Xiong H (ref27) 2015; 103 Chattopadhyay P (ref3) 2012; 4 Vu PX (ref23) 2007 Yang LR (ref29) 2006; 28 Gill BS (ref6) 2018; 45 Hu P (ref9) 2017; 35 Li MM (ref14) 2014; 77 Hu P (ref8) 2016; 111 Wang Y (ref25) 2014; 70 Ryu KH (ref18) 2010; 74 Winter CA (ref26) 1962; 111 Pandey A (ref17) 2012; 61 Zheng CJ (ref30) 2015; 29 Vinuchakkaravarthy T (ref21) 2011; 7 Okuyama E (ref16) 1998; 46 Suksamrarn A (ref20) 2002; 68 Zheng Y (ref31) 2015; 173 Xu JM (ref28) 2019; 137 Wang LY (ref24) 2017; 80 Ankier SI (ref1) 1974; 27 Chen J (ref4) 2014; 12 Lanhers MC (ref13) 1992; 58 Koster R (ref11) 1952; 18 Dharmasiri MG (ref5) 2003; 87 Vogel HG (ref22) 2008 Yang, LR; Xiong, J; Tan, NH; Chu, HB; Xu, L; Li, MY 2006; 28 Lanhers, MC; Fleurentin, J; Mortier, F; Vinche, A; Younos, C 1992; 58 Koster, R; Anderson, M; de Beer, E 1952; 18 Li, MM; Su, XQ; Sun, J; Gu, YF; Huang, Z; Zeng, KW 2014; 77 Wang, LY; Chen, MH; Wu, J; Sun, H; Liu, W; Qu, YH 2017; 80 Suksamrarn, A; Kumpun, S; Kirtikara, K; Yingyongnarongkul, B; Suksamrarn, S 2002; 68 Xu, JM; Hu, BC; Yuan, L; Wu, YL; Luan, SS; Yuan, T 2019; 137 2006 Singh, DD; Chitra, G; Singh, IP; Bhutani, KK 2005; 44 2005 Ryu, KH; Rhee, HI; Kim, JH; Yoo, H; Lee, BY; Um, KA 2010; 74 Dharmasiri, MG; Jayakody, JRAC; Galhena, G; Liyanage, SSP; Ratnasooriya, WD 2003; 87 Hu, P; Li, DH; Hu, X; Li, SG; Sai, CM; Sun, XC 2016; 111 Pandey, A; Bani, S; Satti, NK; Gupta, BD; Suri, KA 2012; 61 Baghdikian, B; Lanhers, MC; Fleurentin, J; Ollivier, E; Maillard, C; Balansard, G 1997; 63 Ankier, SI 1974; 27 Okuyama, E; Fujimori, S; Yamazaki, M; Deyama, T 1998; 46 Vu, PX 2007 Zheng, CJ; Li, HQ; Ren, SC; Xu, CL; Rahman, K; Qin, LP 2015; 29 Wang, Y; Zhang, R; Xie, J; Lu, J; Yue, Z 2014; 70 Vogel, HG 2008 Chattopadhyay, P; Hazarika, S; Dhiman, S; Upadhyay, A; Pandey, A; Karmakar, S 2012; 4 Kulkarni, RR; Virkar, DA; D’Mello, Priscilla 2008; 70 Zheng, Y; Yin, X; Huo, F; Xiong, H; Mei, Z 2015; 173 Chen, J; Fan, CL; Wang, Y; Ye, WC 2014; 12 Gill, BS; Mehra, R; Navgeet,; Kumar, S 2018; 45 Vinuchakkaravarthy, T; Kumaravel, KP; Ravichandran, S; Velmurugan, D 2011; 7 Winter, CA; Risley, EA; Nuss, GW 1962; 111 Xiong, H; Zheng, Y; Yang, G; Wang, H; Mei, Z 2015; 103 Gupta, RK; Tandon, VR 2005; 49 Hu, P; Li, DH; Jia, CC; Liu, Q; Wang, XF; Li, ZL 2017; 35 |
| References_xml | – volume: 111 start-page: 147 year: 2016 ident: ref8 article-title: Lignans and triterpenoids from Vitex negundo var. heterophylla and their biological evaluation publication-title: Fitoterapia doi: 10.1016/j.fitote.2016.04.020 contributor: fullname: Hu P – volume: 103 start-page: 33 year: 2015 ident: ref27 article-title: Triterpene saponins with anti-inflammatory activity from the stems of Entada phaseoloides publication-title: Fitoterapia doi: 10.1016/j.fitote.2015.03.001 contributor: fullname: Xiong H – volume: 12 start-page: 218 issue: 3 year: 2014 ident: ref4 article-title: A new triterpenoid glycoside from Vitex negundo publication-title: Chin J Nat Med contributor: fullname: Chen J – volume: 45 start-page: 2925 issue: 6 year: 2018 ident: ref6 article-title: Vitex negundo and its medicinal value publication-title: Mol Biol Rep doi: 10.1007/s11033-018-4421-3 contributor: fullname: Gill BS – volume: 27 start-page: 1 issue: 1 year: 1974 ident: ref1 article-title: New hot plate tests to quantify antinociceptive and narcotic antagonist activities publication-title: Eur J Pharmacol doi: 10.1016/0014-2999(74)90195-2 contributor: fullname: Ankier SI – start-page: 984 year: 2008 ident: ref22 contributor: fullname: Vogel HG – volume: 61 start-page: 293 issue: 4 year: 2012 ident: ref17 article-title: Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines publication-title: Inflamm Res doi: 10.1007/s00011-011-0410-x contributor: fullname: Pandey A – volume: 35 start-page: 236 year: 2017 ident: ref9 article-title: Bioactive constituents from Vitex negundo var. heterophylla and their antioxidant and α-glucosidase inhibitory activities publication-title: J Funct Foods doi: 10.1016/j.jff.2017.05.047 contributor: fullname: Hu P – volume: 87 start-page: 199 issue: 2 year: 2003 ident: ref5 article-title: Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo publication-title: J Ethnopharmacol doi: 10.1016/S0378-8741(03)00159-4 contributor: fullname: Dharmasiri MG – volume: 49 start-page: 163 issue: 2 year: 2005 ident: ref7 article-title: Antinociceptive activity of Vitex negundo Linn leaf extract publication-title: Indian J Physiol Pharmacol contributor: fullname: Gupta RK – volume: 111 start-page: 544 year: 1962 ident: ref26 article-title: Carrageenin induced edema in hind paw of the rat as an assay for anti-inflamatoly drug publication-title: Proc. Soc. Exp. Biol doi: 10.3181/00379727-111-27849 contributor: fullname: Winter CA – volume: 4 start-page: 134 issue: 3 year: 2012 ident: ref3 article-title: Vitex negundo inhibits cyclooxygenase-2 inflammatory cytokine-mediated inflammation on carrageenan-induced rat hind paw edema publication-title: Pharmacognosy Res doi: 10.4103/0974-8490.99072 contributor: fullname: Chattopadhyay P – volume: 44 start-page: 1288 year: 2005 ident: ref19 article-title: Immunostimulatory compounds from Vitex negundo publication-title: Indian J Chem B contributor: fullname: Singh DD – volume: 63 start-page: 171 issue: 2 year: 1997 ident: ref2 article-title: An analytical study, anti-inflammatory and analgesic effects of Harpagophytum procumbens and Harpagophytum zeyheri publication-title: Planta Med doi: 10.1055/s-2006-957638 contributor: fullname: Baghdikian B – volume: 74 start-page: 2022 issue: 10 year: 2010 ident: ref18 article-title: Anti-inflammatory and analgesic activities of SKLJI, a highly purified and injectable herbal extract of Lonicera japonica publication-title: Biosci Biotechnol Biochem doi: 10.1271/bbb.100279 contributor: fullname: Ryu KH – volume: 137 start-page: 104265 year: 2019 ident: ref28 article-title: Labdanes and megastigmanes from Vitex negundo var. heterophylla publication-title: Fitoterapia doi: 10.1016/j.fitote.2019.104265 contributor: fullname: Xu JM – volume: 80 start-page: 1808 issue: 6 year: 2017 ident: ref24 article-title: Bioactive glycosides from the twigs of Litsea cubeba publication-title: J Nat Prod doi: 10.1021/acs.jnatprod.6b01189 contributor: fullname: Wang LY – volume: 70 start-page: 1565 issue: 3 year: 2014 ident: ref25 article-title: Analgesic activity of catalpol in rodent models of neuropathic pain, and its spinal mechanism publication-title: J Cell Biochem contributor: fullname: Wang Y – year: 2007 ident: ref23 contributor: fullname: Vu PX – volume: 28 start-page: 553 issue: 5 year: 2006 ident: ref29 article-title: Chemical constituents of Pedicularis tricolor (Scrophulariaceae) publication-title: Acta Botanica Yunnanica contributor: fullname: Yang LR – volume: 46 start-page: 655 issue: 4 year: 1998 ident: ref16 article-title: Pharmacologically active components of Viticis fructus (Vitex rotundifolia). II. The component having analgesic effects publication-title: Chem Pharm Bull doi: 10.1248/cpb.46.655 contributor: fullname: Okuyama E – year: 2006 ident: ref15 – volume: 58 start-page: 117 issue: 2 year: 1992 ident: ref13 article-title: Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens publication-title: Planta Med doi: 10.1055/s-2006-961411 contributor: fullname: Lanhers MC – volume: 173 start-page: 204 year: 2015 ident: ref31 article-title: Analgesic effects and possible mechanisms of iridoid glycosides from Lamiophlomis rotata (Benth.) Kudo in rats with spared nerve injury publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2015.06.045 contributor: fullname: Zheng Y – volume: 68 start-page: 72 issue: 1 year: 2002 ident: ref20 article-title: Iridoids with anti-inflammatory activity from Vitex peduncularis publication-title: Planta Med doi: 10.1055/s-2002-20048 contributor: fullname: Suksamrarn A – volume: 77 start-page: 2248 issue: 10 year: 2014 ident: ref14 article-title: Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia publication-title: J Nat Prod doi: 10.1021/np500509q contributor: fullname: Li MM – volume: 7 start-page: 199 issue: 4 year: 2011 ident: ref21 article-title: Active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A(2) through molecular docking publication-title: Bioinformation doi: 10.6026/97320630007199 contributor: fullname: Vinuchakkaravarthy T – volume: 29 start-page: 633 issue: 5 year: 2015 ident: ref30 article-title: Phytochemical and pharmacological profile of Vitex negundo publication-title: Phytother Res doi: 10.1002/ptr.5303 contributor: fullname: Zheng CJ – year: 2005 ident: ref10 – volume: 70 start-page: 838 issue: 6 year: 2008 ident: ref12 article-title: Antioxidant and antiinfl ammatory activity of Vitex negundo publication-title: Indian J Pharm Sci doi: 10.4103/0250-474X.49140 contributor: fullname: Kulkarni RR – volume: 18 start-page: 412 year: 1952 ident: ref11 article-title: Acid acetic for analgesic screening publication-title: Fed Proc contributor: fullname: Koster R – volume: 44 start-page: 1288 year: 2005 end-page: 1290 article-title: Immunostimulatory compounds from Vitex negundo publication-title: Indian J Chem B contributor: fullname: Singh, DD; Chitra, G; Singh, IP; Bhutani, KK – volume: 103 start-page: 33 year: 2015 end-page: 45 article-title: Triterpene saponins with anti-inflammatory activity from the stems of Entada phaseoloides publication-title: Fitoterapia contributor: fullname: Xiong, H; Zheng, Y; Yang, G; Wang, H; Mei, Z – volume: 61 start-page: 293 issue: 4 year: 2012 end-page: 304 article-title: Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines publication-title: Inflamm Res contributor: fullname: Pandey, A; Bani, S; Satti, NK; Gupta, BD; Suri, KA – volume: 173 start-page: 204 year: 2015 end-page: 211 article-title: Analgesic effects and possible mechanisms of iridoid glycosides from Lamiophlomis rotata (Benth.) Kudo in rats with spared nerve injury publication-title: J Ethnopharmacol contributor: fullname: Zheng, Y; Yin, X; Huo, F; Xiong, H; Mei, Z – volume: 70 start-page: 838 issue: 6 year: 2008 end-page: 840 article-title: Antioxidant and antiinfl ammatory activity of Vitex negundo publication-title: Indian J Pharm Sci contributor: fullname: Kulkarni, RR; Virkar, DA; D’Mello, Priscilla – volume: 87 start-page: 199 issue: 2 year: 2003 end-page: 206 article-title: Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo publication-title: J Ethnopharmacol contributor: fullname: Dharmasiri, MG; Jayakody, JRAC; Galhena, G; Liyanage, SSP; Ratnasooriya, WD – volume: 80 start-page: 1808 issue: 6 year: 2017 end-page: 1818 article-title: Bioactive glycosides from the twigs of Litsea cubeba publication-title: J Nat Prod contributor: fullname: Wang, LY; Chen, MH; Wu, J; Sun, H; Liu, W; Qu, YH – volume: 111 start-page: 147 year: 2016 end-page: 153 article-title: Lignans and triterpenoids from Vitex negundo var. heterophylla and their biological evaluation publication-title: Fitoterapia contributor: fullname: Hu, P; Li, DH; Hu, X; Li, SG; Sai, CM; Sun, XC – volume: 58 start-page: 117 issue: 2 year: 1992 end-page: 123 article-title: Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens publication-title: Planta Med contributor: fullname: Lanhers, MC; Fleurentin, J; Mortier, F; Vinche, A; Younos, C – volume: 18 start-page: 412 year: 1952 end-page: 412 article-title: Acid acetic for analgesic screening publication-title: Fed Proc contributor: fullname: Koster, R; Anderson, M; de Beer, E – volume: 63 start-page: 171 issue: 2 year: 1997 end-page: 176 article-title: An analytical study, anti-inflammatory and analgesic effects of Harpagophytum procumbens and Harpagophytum zeyheri publication-title: Planta Med contributor: fullname: Baghdikian, B; Lanhers, MC; Fleurentin, J; Ollivier, E; Maillard, C; Balansard, G – volume: 12 start-page: 218 issue: 3 year: 2014 end-page: 221 article-title: A new triterpenoid glycoside from Vitex negundo publication-title: Chin J Nat Med contributor: fullname: Chen, J; Fan, CL; Wang, Y; Ye, WC – volume: 46 start-page: 655 issue: 4 year: 1998 end-page: 662 article-title: Pharmacologically active components of Viticis fructus (Vitex rotundifolia). II. The component having analgesic effects publication-title: Chem Pharm Bull contributor: fullname: Okuyama, E; Fujimori, S; Yamazaki, M; Deyama, T – volume: 45 start-page: 2925 issue: 6 year: 2018 end-page: 2934 article-title: Vitex negundo and its medicinal value publication-title: Mol Biol Rep contributor: fullname: Gill, BS; Mehra, R; Navgeet,; Kumar, S – volume: 49 start-page: 163 issue: 2 year: 2005 end-page: 170 article-title: Antinociceptive activity of Vitex negundo Linn leaf extract publication-title: Indian J Physiol Pharmacol contributor: fullname: Gupta, RK; Tandon, VR – year: 2007 publication-title: Vietnam flora contributor: fullname: Vu, PX – volume: 4 start-page: 134 issue: 3 year: 2012 end-page: 137 article-title: Vitex negundo inhibits cyclooxygenase-2 inflammatory cytokine-mediated inflammation on carrageenan-induced rat hind paw edema publication-title: Pharmacognosy Res contributor: fullname: Chattopadhyay, P; Hazarika, S; Dhiman, S; Upadhyay, A; Pandey, A; Karmakar, S – year: 2005 publication-title: ICH Harmonised Tripartite Guideline: Validation of Analytical Procedures: Text and Methodology Q2(R1) – start-page: 984 year: 2008 end-page: 1116 publication-title: Analgesic, Anti-Inflammatory, and Anti-Pyretic Activity. In: Drug discovery and evaluation: pharmacological assays contributor: fullname: Vogel, HG – year: 2006 publication-title: National Institute of Medicinal Materials, Medicinal plants and animals in Vietnam – volume: 70 start-page: 1565 issue: 3 year: 2014 end-page: 1571 article-title: Analgesic activity of catalpol in rodent models of neuropathic pain, and its spinal mechanism publication-title: J Cell Biochem contributor: fullname: Wang, Y; Zhang, R; Xie, J; Lu, J; Yue, Z – volume: 111 start-page: 544 year: 1962 end-page: 574 article-title: Carrageenin induced edema in hind paw of the rat as an assay for anti-inflamatoly drug publication-title: Proc. Soc. Exp. Biol contributor: fullname: Winter, CA; Risley, EA; Nuss, GW – volume: 29 start-page: 633 issue: 5 year: 2015 end-page: 647 article-title: Phytochemical and pharmacological profile of Vitex negundo publication-title: Phytother Res contributor: fullname: Zheng, CJ; Li, HQ; Ren, SC; Xu, CL; Rahman, K; Qin, LP – volume: 27 start-page: 1 issue: 1 year: 1974 end-page: 4 article-title: New hot plate tests to quantify antinociceptive and narcotic antagonist activities publication-title: Eur J Pharmacol contributor: fullname: Ankier, SI – volume: 68 start-page: 72 issue: 1 year: 2002 end-page: 73 article-title: Iridoids with anti-inflammatory activity from Vitex peduncularis publication-title: Planta Med contributor: fullname: Suksamrarn, A; Kumpun, S; Kirtikara, K; Yingyongnarongkul, B; Suksamrarn, S – volume: 35 start-page: 236 year: 2017 end-page: 244 article-title: Bioactive constituents from Vitex negundo var. heterophylla and their antioxidant and α-glucosidase inhibitory activities publication-title: J Funct Foods contributor: fullname: Hu, P; Li, DH; Jia, CC; Liu, Q; Wang, XF; Li, ZL – volume: 7 start-page: 199 issue: 4 year: 2011 end-page: 206 article-title: Active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A(2) through molecular docking publication-title: Bioinformation contributor: fullname: Vinuchakkaravarthy, T; Kumaravel, KP; Ravichandran, S; Velmurugan, D – volume: 77 start-page: 2248 issue: 10 year: 2014 end-page: 2254 article-title: Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia publication-title: J Nat Prod contributor: fullname: Li, MM; Su, XQ; Sun, J; Gu, YF; Huang, Z; Zeng, KW – volume: 74 start-page: 2022 issue: 10 year: 2010 end-page: 2028 article-title: Anti-inflammatory and analgesic activities of SKLJI, a highly purified and injectable herbal extract of Lonicera japonica publication-title: Biosci Biotechnol Biochem contributor: fullname: Ryu, KH; Rhee, HI; Kim, JH; Yoo, H; Lee, BY; Um, KA – volume: 137 start-page: 104265 year: 2019 end-page: 104265 article-title: Labdanes and megastigmanes from Vitex negundo var. heterophylla publication-title: Fitoterapia contributor: fullname: Xu, JM; Hu, BC; Yuan, L; Wu, YL; Luan, SS; Yuan, T – volume: 28 start-page: 553 issue: 5 year: 2006 end-page: 557 article-title: Chemical constituents of Pedicularis tricolor (Scrophulariaceae) publication-title: Acta Botanica Yunnanica contributor: fullname: Yang, LR; Xiong, J; Tan, NH; Chu, HB; Xu, L; Li, MY |
| SSID | ssj0001548945 |
| Score | 2.2943556 |
| Snippet | Abstract The phytochemical investigation on Vitex negundo leaves has led to the isolation of one new iridoid glucoside... |
| SourceID | doaj scielo crossref |
| SourceType | Open Website Open Access Repository Aggregation Database |
| SubjectTerms | Analgesic Anti-inflammatory HPLC quantification Iridoid PHARMACOLOGY & PHARMACY Vitex negundo |
| Title | Phytochemical investigation on Vitex negundo leaves and their anti-inflammatory and analgesic activities |
| URI | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100698&lng=en&tlng=en https://doaj.org/article/23bd7292f9e34be38765bc7f49515099 |
| Volume | 58 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELVQT1xQW0AspcgHtFxqbRJ_jY8FUSok0Eq0aG-WndjdSiWL2BR1_z1jO7C7Jy5IURTFURx5xpr37MwbQt4oSLuZrWAKAwITKgTmo2pZpaqYKoo4F1OC8-cv6vJafFrIxU6pr_RPWJEHLgM3a7jvEAA20QQufOA4e6VvdURgj1jGlNS9yuyQqZIfLMAIOebKSVPN1oi9JTPaID5qmoDcXfG9WJQl-5NgKM6pu90gc3FInozokJ6Xrzoij0J_TKbzIi-9OaNX22yp9Rmd0vlWeHrzlCzny82QKmBlCQB6u5XQWPUUj28ILx9oH27u-25F74LDdur6jubdArwabhk6HPrI97z3nttcnyqBoC1pSoH4lQVYn5Hriw9X7y_ZWEmBtcgPB6Z4V6mm5hpa5w20uhG6akGFaLTDJogY1zsF0gVAysARc4gawEMtpBfc8-fkoF_14QWhEHUVjVfScS7QKg60lo1rHASHTBsmhP0ZU_ujCGbYRDTQBjbbwO7bYELepYH_-2ySu8430Ans6AT2X04wIW-L2ew4A9f2a21AWOS_ua_kEkmUGV7-j-5OyOP00rIS84ocDD_vwylik8G_zm6I54-L-jdbTd23 |
| link.rule.ids | 230,315,783,787,867,888,2109,27937,27938 |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Phytochemical+investigation+on+Vitex+negundo+leaves+and+their+anti-inflammatory+and+analgesic+activities&rft.jtitle=Brazilian+Journal+of+Pharmaceutical+Sciences&rft.au=Tu+Thanh+Thi+Nguyen&rft.au=Phuong+Thi+Do&rft.au=Anh+Van+Thi+Pham&rft.au=Huong+Giang+Thi+Tran+Nguyen&rft.date=2022-01-01&rft.pub=Universidade+de+S%C3%A3o+Paulo&rft.eissn=2175-9790&rft.volume=58&rft_id=info:doi/10.1590%2Fs2175-97902022e19463&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_23bd7292f9e34be38765bc7f49515099 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2175-9790&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2175-9790&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2175-9790&client=summon |