Biocompatible chitosan-pectin polyelectrolyte complex for simultaneous electrochemical determination of metronidazole and metribuzin

• Published in: Carbohydrate polymers Vol. 214; pp. 317 - 327
• Main Authors: Ranganathan, Palraj, Mutharani, Bhuvanenthiran, Chen, Shen-Ming, Sireesha, Pedaballi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.06.2019
• Subjects: Anti-Bacterial Agents - blood; Anti-Bacterial Agents - chemistry; Biocompatible Materials - chemistry; Biopolyelectrolyte; Carbon - chemistry; Chitosan - chemical synthesis; Chitosan - chemistry; Electrochemical Techniques - instrumentation; Electrochemical Techniques - methods; Electrodes; Green Chemistry Technology - methods; Herbicides - blood; Herbicides - chemistry; Humans; Limit of Detection; Metribuzin; Metronidazole; Metronidazole - blood; Metronidazole - chemistry; Molecular Weight; Oxidation-Reduction; Pectins - chemical synthesis; Pectins - chemistry; Polyelectrolytes - chemistry; Reproducibility of Results; Simultaneous determination; Triazines - blood; Triazines - chemistry; Viscosity; Simultaneous determination; Metronidazole; Biopolyelectrolyte; Metribuzin
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2019.03.053

[Display omitted] •Biocompatible CS-PC BPE was used to the electrochemical sensing for the first time.•The CS-PC BPE/GCE revealed excellent electrocatalytic activity towards MNZ and MTZ.•High selectivity for MNZ and MTZ and nanomolar level detection limit were observed.•The method was successfully applied for real sample analysis. Development of novel biocompatible sensor material suitable for modest, cost-effective, and rapid practical application is a demanding research interest in the field of electroanalytical chemistry. In this context, for the first time, we utilized biocompatible chitosan-pectin biopolyelectrolyte (CS-PC BPE) complex for the simultaneous electroreduction of an important antibiotic drug (metronidazole-MNZ) and herbicide (metribuzin-MTZ). This sensor reveals an attractive welfares such as simplicity, biocompatibility, and low production cost. Under optimized experimental conditions, the electroanalytical investigation confirmed that CS-PC BPE modified glassy carbon electrode (CS-PC BPE/GCE) was found to sense MNZ and MTZ in the nanomolar range. Moreover, as-prepared CS-PC BPE/GCE exhibited prominent selectivity, stability, and reproducibility. Additionally, the possible MNZ and MTZ sensing mechanism of CS-PC BPE/GCE have been discussed in detail. Lastly, real sample analysis was also carried out and revealed from several investigations that the CS-PC BPE/GCE is a good electrochemical sensor system for the detection of targeted analytes.