New 24-membered macrolides SPA-6952A and B produced by Streptomyces sp

Two new 24-membered macrolides, SPA-6952A and B, were isolated from the fermentation broth of Streptomyces sp. SPA-6952. The structures of the new macrolides were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited cytotoxic activity against human promyelocytic le...

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Bibliographic Details
Published inJournal of antibiotics Vol. 58; no. 6; pp. 409 - 411
Main Authors Hosotani, N, Kumagai, K, Nakagawa, H, Shimatani, T, Saji
Format Journal Article
LanguageEnglish
Published TOKYO Japan Antibiotics Research Assoc 01.06.2005
Nature Publishing Group
Subjects
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Biotechnology & Applied Microbiology
Chromatography, High Pressure Liquid
Fermentation
HL-60 Cells
Humans
Immunology
Leukemia
Life Sciences & Biomedicine
Macrolides - isolation & purification
Macrolides - metabolism
Macrolides - pharmacology
Microbiology
Molecular Conformation
Pharmacology & Pharmacy
Science & Technology
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Streptomyces - metabolism
Streptomyces
cytotoxic activity
antimicrobial activity
macrolide
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Summary:Two new 24-membered macrolides, SPA-6952A and B, were isolated from the fermentation broth of Streptomyces sp. SPA-6952. The structures of the new macrolides were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited cytotoxic activity against human promyelocytic leukemia HL-60 cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2005.52