Age-related differences in network flexibility and segregation at rest and during motor performance

• Published in: NeuroImage (Orlando, Fla.) Vol. 194; pp. 93 - 104
• Main Authors: Monteiro, T.S., King, B.R., Zivari Adab, H., Mantini, D., Swinnen, S.P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2019; Elsevier Limited
• Subjects: Age; Aged; Ageing; Aging; Aging - physiology; Bimanual coordination; Brain - physiology; Brain research; Cerebellum; Female; Flexibility; Functional connectivity; Functional magnetic resonance imaging; Humans; Learning - physiology; Male; Motor Activity - physiology; Motor learning; Motor task performance; Neostriatum; Neural networks; Neural Pathways - physiology; Older people; Prefrontal cortex; Rest; Young Adult; Functional connectivity; Bimanual coordination; Motor learning; Ageing
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2019.03.015

Brain networks undergo widespread changes in older age. A large body of knowledge gathered about those changes evidenced an increase of functional connectivity between brain networks. Previous work focused mainly on cortical networks during the resting state. Subcortical structures, however, are of critical importance during the performance of motor tasks. In this study, we investigated age-related changes in cortical, striatal and cerebellar functional connectivity at rest and its modulation by motor task execution. To that end, functional MRI from twenty-five young (mean age 21.5 years) and eighteen older adults (mean age 68.6 years) were analysed during rest and while performing a bimanual tracking task practiced over a two-week period. We found that inter-network connectivity among cortical structures was more positive in older adults both during rest and task performance. Functional connectivity within striatal structures decreased with age during rest and task execution. Network flexibility, the changes in network composition from rest to task, was also reduced in older adults, but only in networks with an age-related increase in connectivity. Finally, flexibility of areas in the prefrontal cortex were associated with lower error scores during task execution, especially in older adults. In conclusion, our findings indicate an age-related reduction in the ability to suppress irrelevant network communication, leading to less segregated and less flexible cortical networks. At the same time, striatal connectivity is impaired in older adults, while cerebellar connectivity shows heterogeneous age-related effects during rest and task execution. Future research is needed to clarify how cortical and subcortical connectivity changes relate to one another. •Age-related reduced network segregation at rest is not changed by task demands.•Older age is associated with increased cortical, but reduced striatal, connectivity.•Less segregated networks show reduced flexibility in older adults.•Prefrontal network flexibility is associated with better bimanual performance.