Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions
BACKGROUND: This study compared Th1–Th2 cytokine profiles in a subgroup of recurrent aborters who had an abortion with those in a subgroup of recurrent aborters who had a successful pregnancy. METHODS: Fifty-four women with a history of at least three normal pregnancies, 24 women with a history of r...
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Published in | Human reproduction (Oxford) Vol. 16; no. 10; pp. 2219 - 2226 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
01.10.2001
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Subjects | |
Online Access | Get full text |
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Summary: | BACKGROUND: This study compared Th1–Th2 cytokine profiles in a subgroup of recurrent aborters who had an abortion with those in a subgroup of recurrent aborters who had a successful pregnancy. METHODS: Fifty-four women with a history of at least three normal pregnancies, 24 women with a history of recurrent spontaneous abortion (RSA) followed by abortion (RSA→A) and 39 women with a history of RSA followed by normal pregnancy (RSA→N) were studied. Blood samples and placentas were obtained at the time of delivery or abortion; peripheral blood mononuclear cells were stimulated separately with phytohaemagglutinin and with autologous placental cells, and the secreted cytokines estimated. RESULTS: Peripheral blood mononuclear cells from the RSA→N subgroup secreted higher concentrations of Th1-type cytokines as compared with normal pregnant women, indicating a higher Th1 bias in these women. However, women in the RSA→N subgroup had significantly higher concentrations of Th2 cytokines as compared with women in the RSA→A subgroup. A comparison of Th1:Th2 cytokine ratios indicated a higher Th2 bias in RSA→N women as compared with RSA→A women. CONCLUSIONS: We conclude that abortion-prone women who proceed to have successful pregnancy are more Th2-biased than abortion-prone women who abort, and that recurrent aborters who undergo spontaneous abortion have a stronger Th1 bias than aborters who have normal pregnancy. |
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Bibliography: | local:0162219 ark:/67375/HXZ-WBBXN0GK-1 istex:8CD3592DA0FDD69BE7C5997257D118CB5D7F130F PII:1460-2350 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0268-1161 1460-2350 |
DOI: | 10.1093/humrep/16.10.2219 |