A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)

Isatin, chemically an indole-1 -2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by the increasing number of isatin-based molecules...

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Published inPharmaceuticals (Basel, Switzerland) Vol. 15; no. 5; p. 536
Main Authors Chowdhary, Shefali, Shalini, Arora, Amandeep, Kumar, Vipan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.04.2022
MDPI
Subjects
antimicrobials
antimycobacterials
antiplasmodials
antiproliferatives
Apoptosis
Binding sites
Cancer
Cell cycle
Clinical trials
isatin
Review
Tropical diseases
Tumors
antiproliferatives
antimicrobials
isatin
antimycobacterials
antiplasmodials
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Summary:Isatin, chemically an indole-1 -2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by the increasing number of isatin-based molecules which are either in clinical use or in trials. Apart from its promising antiproliferative properties, isatin has shown potential in treating Neglected Tropical Diseases (NTDs) not only as a parent core, but also by attenuating the activities of various pharmacophores. The objective of this mini-review is to keep readers up to date on the latest developments in the biological potential of isatin-based scaffolds, targeting cancer and NTDs such as tuberculosis, malaria, and microbial infections.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1424-8247
1424-8247
DOI:10.3390/ph15050536