Rational synthesis of rare-earth lanthanum molybdate covered reduced graphene oxide nanocomposites for the voltammetric detection of Moxifloxacin hydrochloride

• Published in: Bioelectrochemistry (Amsterdam, Netherlands) Vol. 146; p. 108145
• Main Authors: Akilarasan, Muthumariappan, Tamilalagan, Elayappan, Chen, Shen-Ming, Maheshwaran, Selvarasu, Fan, Chih-Hsuan, Habila, Mohamed A., Sillanpää, Mika
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2022; Elsevier BV
• Subjects: Binary-metal oxide; Drug analysis; Electrocatalysts; Electrochemical sensor; Electronic structure; Glassy carbon; Graphene; La2(MoO4)3@rGO nanocomposites; Lanthanum; Metal oxides; Metal-organic frameworks; Molybdate; Moxifloxacin; Moxifloxacin hydrochloride sensor; Nanocomposites; Nanomaterials; Nanotechnology; Perovskite structure; Perovskites; Physicochemical analysis; Raman spectroscopy; Rare earth elements; Reproducibility; Selectivity; Stability analysis; Voltammetry; La2(MoO4)3@rGO nanocomposites; Electrochemical sensor; Drug analysis; Moxifloxacin hydrochloride sensor; Binary-metal oxide; La(MoO)@rGO nanocomposites
• ISSN: 1567-5394; 1878-562X
• DOI: 10.1016/j.bioelechem.2022.108145

•La2(MoO4)3@rGO nanocomposites with more active sites/edges were synthesised.•La2(MoO4)3@rGO possessed the rapid heterogenous electron transfer towards MHZ.•The developed sensor detect the MOF with the detection limit of 2.84 nM.•Practical analysis of prepared sensor shows good recoveries on clinical samples. Recently, perovskite structure-based metal oxide nanomaterials and their composites opted for electrocatalyst because of its excellent conductivity, unique, and favored electronic structure. In this attempt, herein we prepared the rare earth mixed metal molybdate covered reduced graphene oxide La2(MoO4)3@rGO nanocomposites by a simple hydrothermal method for the sensitive detection of Moxifloxacin hydrochloride (MOF) in pharmaceutical and human urine samples. The various physicochemical analysis such as SEM, TEM, XRD and Raman spectroscopy confirms the successful formation of (La2(MoO4)3@rGO) nanocomposites. Furthermore, the electroanalytical performance of La2(MoO4)3@rGO modified glassy carbon electrode (La2(MoO4)3@rGO/GCE) was analyzed using the cyclic voltammetry (CV) and differential pulse voltammetry (DPV) which shows excellent results with a wide range of 1.0 × 10−8 M to 6.0 × 10−4 M and the detection limit of 2.84 × 10−9 M towards the MOF detection. Furthermore, the developed sensor expressed good selectivity, repeatability, stability and reproducibility. Finally, the real sample analysis of the developed sensor was tested in the MOF tablets and human urine samples, which shows the appreciable recoveries.