Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice

[Figure: see text].

Saved in:
Bibliographic Details
Published inArteriosclerosis, thrombosis, and vascular biology Vol. 41; no. 11; pp. 2773 - 2785
Main Authors Xiong, Shiqin, Zhang, Lianghui, Richner, Justin M, Class, Jake, Rehman, Jalees, Malik, Asrar B
Format Journal Article
LanguageEnglish
Published United States Lippincott Williams & Wilkins 01.11.2021
Subjects
Animals
Antigens, CD - metabolism
Basic Sciences
Cadherins - metabolism
Capillary Permeability
Caspase 1 - metabolism
COVID-19 - complications
COVID-19 - physiopathology
COVID-19 Drug Treatment
Disease Models, Animal
Down-Regulation - drug effects
Edema - physiopathology
Edema - prevention & control
Endothelium, Vascular - drug effects
Enzyme Activation
Fibrosis - prevention & control
Interleukin 1 Receptor Antagonist Protein - therapeutic use
Mice
Mice, Inbred C57BL
Mice, Transgenic
Neutrophils - physiology
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
Pulmonary Circulation
Receptors, Interleukin-1 - antagonists & inhibitors
Receptors, Interleukin-1 - physiology
SARS-CoV-2
Signal Transduction - drug effects
pyroptosis
SARS-CoV-2
interleukin-1
vascular system injur
edema
ies
Online AccessGet full text

Cover

More Information
Summary:[Figure: see text].
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1079-5642
1524-4636
1524-4636
DOI:10.1161/ATVBAHA.121.316925