Advances in triterpene drug discovery

AbstractTriterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and harness triterpene structural diversity using engineering biology ap...

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Bibliographic Details
Published inTrends in pharmacological sciences (Regular ed.) Vol. 45; no. 11; pp. 964 - 968
Main Authors Goddard, Zoë R, Searcey, Mark, Osbourn, Anne
Format Journal Article
LanguageEnglish
Published England 01.11.2024
Subjects
Advanced Basic Science
Animals
Biological Products - chemistry
Biological Products - pharmacology
Drug Discovery - methods
Humans
Triterpenes - chemistry
Triterpenes - pharmacology
plant natural products
metabolic engineering
drug discovery
triterpenes
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Summary:AbstractTriterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and harness triterpene structural diversity using engineering biology approaches, enabling the discovery and optimisation of a new generation of drug leads.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:0165-6147
1873-3735
1873-3735
DOI:10.1016/j.tips.2024.10.003