Polysaccharides purified from Cordyceps cicadae protects PC12 cells against glutamate-induced oxidative damage

• Published in: Carbohydrate polymers Vol. 153; pp. 187 - 195
• Main Authors: Olatunji, Opeyemi J., Feng, Yan, Olatunji, Oyenike O., Tang, Jian, Wei, Yuan, Ouyang, Zhen, Su, Zhaoliang
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 20.11.2016
• Subjects: Cordyceps cicadae; Glutamate; Neuroprotection; PC12 cells; Polysaccharide; Neuroprotection; Glutamate; Polysaccharide; PC12 cells; Cordyceps cicadae

•Two polysaccharides CPA-1 and CPB-2 were purified from Cordyceps cicadae.•CPA-1 and CPB-2 protected PC12 cells from glutamate induced toxicity by increasing cell survival rate, decreasing the accumulation of ROS and Ca2+.•CPA-1 and CPB-2 increased GSH-Px and SOD activites. Two polysaccharides CPA-1...