Dietary prevention of allergic diseases in infants and small children. Part III: Critical review of published peer-reviewed observational and interventional studies and final recommendations

• Published in: Pediatric allergy and immunology Vol. 15; no. 4; pp. 291 - 307
• Main Authors: MURARO, Antonella, DREBORG, Sten, EIGENMANN, Philippe, HILL, David, JONES, Catherine, MELLON, Michael, OLDEUS, Göran, ORANJE, Arnold, PASCUAL, Cristina, PRESCOTT, Susan, SAMPSON, Hugh, SVARTENGREN, Magnus, HALKEN, Susanne, VANDENPLAS, Yvan, WAHN, Ulrich, WARNER, Jill A, WARNER, John O, WICKMAN, Magnus, ZEIGER, Robert S, HØST, Arne, NIGGEMANN, Bodo, AALBERSE, Rob, ARSHAD, Syed H, VON BERG, Andrea, CARLSEN, Kai-Hakon, DUSCHEN, Karel
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.08.2004
• Subjects: Biological and medical sciences; Breast Feeding; Child, Preschool; Clinical Trials as Topic; Cow's milk allergy; Diet; Food allergy; Fundamental and applied biological sciences. Psychology; Fundamental immunology; General aspects; Humans; Hypersensitivity - prevention & control; Infant; Medical sciences; Medicin och hälsovetenskap; Milk Hypersensitivity - prevention & control; NATURAL SCIENCES; NATURVETENSKAP; Prevention; Review; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Statements of evidence; Human; Immunopathology; Pediatrics; Food allergy; Small; Disease; Statement; breast feeding; cow's milk allergy; food allergy; Infant; Review; Breast feeding; Recommendation; Feeding; Prevention; Immunology; Diet therapy; Diet; Cow milk; Peer review; prevention; review; statements of evidence; Child; Bibliographic review
• ISSN: 0905-6157; 1399-3038; 1399-3038
• DOI: 10.1111/j.1399-3038.2004.00127.x

The role of primary prevention of allergic diseases has been a matter of debate for the last 40 years. In order to shed some light on this issue, a group of experts of the Section of Pediatrics EAACI reviewed critically the existing literature on the subject. An analysis of published peer-reviewed observational and interventional studies was performed following the statements of evidence as defined by WHO. The results of the analysis indicate that breastfeeding is highly recommended for all infants irrespective of atopic heredity. A dietary regimen is unequivocally effective in the prevention of allergic diseases in high-risk children. In these patients breastfeeding combined with avoidance of solid food and cow's milk for at least 4-6 months is the most effective preventive regimen. In the absence of breast milk, formulas with documented reduced allergenicity for at least 4-6 months should be used.