The generation and regulation of human T lymphocytes by Imuthiol. Evidence from an in vitro differentiation induction system

In vitro long term induction of human peripheral blood lymphocytes by sodium diethyldithiocarbamate, DTC (Imuthiol) enhanced the expression of OKT and HLA-DR phenotypic determinants. A population of T-B-DR+ cells was recruited from the null cell population. The increase in OKT+ cells, but not the en...

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Bibliographic Details
Published inInternational journal of immunopharmacology Vol. 7; no. 4; p. 561
Main Authors Pompidou, A, Duchet, N, Cooper, M D, Mace, B, Telvi, L, Coutance, F, Hadden, J W, Renoux, G
Format Journal Article
LanguageEnglish
Published England 1985
Subjects
Antibodies, Monoclonal - immunology
Antigens, Surface - biosynthesis
B-Lymphocytes - drug effects
Cell Differentiation - drug effects
Ditiocarb - pharmacology
Humans
Indicators and Reagents
Killer Cells, Natural - immunology
Leukocyte Count
Lymphocyte Activation - drug effects
Male
Monocytes - immunology
Phenotype
T-Lymphocytes - classification
T-Lymphocytes - immunology
Thiocarbamates - pharmacology
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Summary:In vitro long term induction of human peripheral blood lymphocytes by sodium diethyldithiocarbamate, DTC (Imuthiol) enhanced the expression of OKT and HLA-DR phenotypic determinants. A population of T-B-DR+ cells was recruited from the null cell population. The increase in OKT+ cells, but not the enhanced HLA-DR expression appeared to be macrophage dependent. The surface markers of NK cells, monocytes or the pokeweed mitogen-induced IgM production were not modified. Collectively, the findings indicate that Imuthiol is not a B cell inducer, but is specifically active on the T-cell population in the way it induces the maturation of null cells into OKT+ DR+ lymphocytes.
ISSN:0192-0561
DOI:10.1016/0192-0561(85)90077-3