Phagocytosis and killing of bacteria in aerobic and anaerobic conditions

Regional Public Health Laboratory, General Hospital, Newcastle upon Tyne NE4 6BE Received January 19, 1981 Accepted February 5, 1981 SUMMARY. Phagocytosis and intracellular killing of several facultative anaerobes were observed in aerobic and anaerobic conditions. The presence of anaerobes affected...

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Published inJournal of medical microbiology Vol. 14; no. 4; pp. 391 - 399
Main Authors INGHAM, H. R, SISSON, PENELOPE R, MIDDLETON, ROSEMARY L, NARANG, H. K, CODD, A. A, SELKON, J. B
Format Journal Article
LanguageEnglish
Published England Soc General Microbiol 01.11.1981
Subjects
Aerobiosis
Anaerobiosis
Bacteroides - physiology
Bacteroides fragilis
Blood Bactericidal Activity
Enterobacteriaceae - physiology
Enterococcus faecalis - physiology
Hot Temperature
Humans
Metronidazole - pharmacology
Oxidation-Reduction
Phagocytes - microbiology
Phagocytosis - drug effects
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Summary:Regional Public Health Laboratory, General Hospital, Newcastle upon Tyne NE4 6BE Received January 19, 1981 Accepted February 5, 1981 SUMMARY. Phagocytosis and intracellular killing of several facultative anaerobes were observed in aerobic and anaerobic conditions. The presence of anaerobes affected these processes. Bacteroides asaccharolyticus and B. fragilis were killed by phagocytes only at bacterial concentrations less than 1 x 10 7 cfu/ml; at higher concentrations of the anaerobes, killing of B. fragilis and concomitant facultative anaerobes was inhibited. This effect appeared to be due to an interaction, in appropriate reducing conditions, between anaerobe and serum, which allowed engulfment of organisms by phagocytes but markedly impaired intracellular killing.
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ISSN:0022-2615
1473-5644
DOI:10.1099/00222615-14-4-391