Ethambutol-induced thrombocytopenia

Extreme thrombocytopenia, purpura, and melena developed in a 71-year-old woman four days after ethambutol administration was started. The macrophage inhibition factor test was positive for ethambutol, and the thrombocytopenia subsided shortly after discontinuation of the drug therapy. The sequence o...

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Bibliographic Details
Published inChest Vol. 81; no. 6; p. 765
Main Authors Rabinovitz, M, Pitlik, S D, Halevy, J, Rosenfeld, J B
Format Journal Article
LanguageEnglish
Published United States 01.06.1982
Subjects
Aged
Drug Therapy, Combination
Ethambutol - adverse effects
Female
Humans
Thrombocytopenia - chemically induced
Tuberculosis - drug therapy
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Summary:Extreme thrombocytopenia, purpura, and melena developed in a 71-year-old woman four days after ethambutol administration was started. The macrophage inhibition factor test was positive for ethambutol, and the thrombocytopenia subsided shortly after discontinuation of the drug therapy. The sequence of events in this patient suggests that, although previously unreported, thrombocytopenia should be added to the list of side effects of ethambutol.
ISSN:0012-3692
1931-3543
DOI:10.1378/chest.81.6.765